BDBM50034864 (S)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamino)-pentanoic acid::CHEMBL46081

SMILES: OC(=O)CC[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)CCC(O)=O

InChI Key: InChIKey=VRSUMLWKSZXAQR-SFHVURJKSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50034864   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neprilysin (Homo sapiens (Human))	BDBM50034864 ((S)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamino)-p...) Show SMILES OC(=O)CC[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)CCC(O)=O Show InChI InChI=1S/C21H23NO5/c23-19(11-13-21(26)27)22-18(10-12-20(24)25)14-15-6-8-17(9-7-15)16-4-2-1-3-5-16/h1-9,18H,10-14H2,(H,22,23)(H,24,25)(H,26,27)/t18-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...				ACS Med Chem Lett 11: 188-194 (2020) Article DOI: 10.1021/acsmedchemlett.9b00578
					More data for this Ligand-Target Pair
Neutral Endopeptidase (NEP) (Rattus norvegicus (Rat))	BDBM50034864 ((S)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamino)-p...) Show SMILES OC(=O)CC[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)CCC(O)=O Show InChI InChI=1S/C21H23NO5/c23-19(11-13-21(26)27)22-18(10-12-20(24)25)14-15-6-8-17(9-7-15)16-4-2-1-3-5-16/h1-9,18H,10-14H2,(H,22,23)(H,24,25)(H,26,27)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	99	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description In vitro inhibition of rat neutral endopeptidase by using GAAP as substrate				J Med Chem 38: 1689-700 (1995) BindingDB Entry DOI: 10.7270/Q2Z89BD0
					More data for this Ligand-Target Pair