BDBM50035787 4-Amino-5-fluoro-1-((2S,5R)-5-hydroxymethyl-tetrahydro-thiophen-2-yl)-1H-pyrimidin-2-one::CHEMBL335193

SMILES: Nc1nc(=O)n(cc1F)[C@@H]1CC[C@H](CO)S1

InChI Key: InChIKey=BAWRQSYFRBPSPK-VDTYLAMSSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50035787   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50035787 (4-Amino-5-fluoro-1-((2S,5R)-5-hydroxymethyl-tetrah...) Show SMILES Nc1nc(=O)n(cc1F)[C@@H]1CC[C@H](CO)S1 Show InChI InChI=1S/C9H12FN3O2S/c10-6-3-13(9(15)12-8(6)11)7-2-1-5(4-14)16-7/h3,5,7,14H,1-2,4H2,(H2,11,12,15)/t5-,7+/m1/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
BioChem Therapeutic Inc. Curated by ChEMBL					Assay Description Ability to inhibit the HIV-1 reverse transcriptase in cord blood mononuclear cells.				J Med Chem 38: 1-4 (1995) BindingDB Entry DOI: 10.7270/Q2VD6XHP
					More data for this Ligand-Target Pair