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BDBM50036065 2-(8-Formyl-1-oxo-3-phenyl-1,9-dihydro-beta-carbolin-2-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-acetamide::CHEMBL424770

SMILES: CC(C)C(NC(=O)Cn1c(O)c2nc3c(C=O)cccc3c2cc1-c1ccccc1)C(=O)C(F)(F)F

InChI Key: InChIKey=KDXPYRURPGRVJT-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50036065   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leukocyte elastase


(Homo sapiens (Human))		BDBM50036065
PNG
(2-(8-Formyl-1-oxo-3-phenyl-1,9-dihydro-beta-carbol...)
Show SMILES CC(C)C(NC(=O)Cn1c(O)c2nc3c(C=O)cccc3c2cc1-c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C26H22F3N3O4/c1-14(2)21(24(35)26(27,28)29)30-20(34)12-32-19(15-7-4-3-5-8-15)11-18-17-10-6-9-16(13-33)22(17)31-23(18)25(32)36/h3-11,13-14,21,36H,12H2,1-2H3,(H,30,34)
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PubMed
 4.90n/an/an/an/an/an/an/an/a



ZENECA Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human leukocyte elastase (HLE) mediated hydrolysis of the synthetic substrate MeOSuc-Ala-Ala-Pro-Val-pNA

J Med Chem 38: 86-97 (1995)


BindingDB Entry DOI: 10.7270/Q2TD9WDR
More data for this
Ligand-Target Pair