BDBM50036296 CHEMBL3353061

SMILES: Cn1ccc2cc(ccc12)C(=O)N1CCn2cc(cc2C1)C(=O)NO

InChI Key: InChIKey=ZVYGMGIDIFWWGW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50036296   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50036296 (CHEMBL3353061) Show SMILES Cn1ccc2cc(ccc12)C(=O)N1CCn2cc(cc2C1)C(=O)NO Show InChI InChI=1S/C18H18N4O3/c1-20-5-4-12-8-13(2-3-16(12)20)18(24)22-7-6-21-10-14(17(23)19-25)9-15(21)11-22/h2-5,8-10,25H,6-7,11H2,1H3,(H,19,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of HDAC6 in human HeLa cells assessed as reduction in K40 hyperacetylation of alpha-tubulin incubated for 6 hrs by immunofluorescence assa...				Bioorg Med Chem Lett 24: 5450-4 (2015) Article DOI: 10.1016/j.bmcl.2014.10.022 BindingDB Entry DOI: 10.7270/Q2B859QH
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50036296 (CHEMBL3353061) Show SMILES Cn1ccc2cc(ccc12)C(=O)N1CCn2cc(cc2C1)C(=O)NO Show InChI InChI=1S/C18H18N4O3/c1-20-5-4-12-8-13(2-3-16(12)20)18(24)22-7-6-21-10-14(17(23)19-25)9-15(21)11-22/h2-5,8-10,25H,6-7,11H2,1H3,(H,19,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	85	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of recombinant N-GST-tagged HDAC6 (unknown origin) assessed as reduction in deacetylation of Ac-Arg-Gly-Lys(Ac)-AMC substrate by fluoresce...				Bioorg Med Chem Lett 24: 5450-4 (2015) Article DOI: 10.1016/j.bmcl.2014.10.022 BindingDB Entry DOI: 10.7270/Q2B859QH
					More data for this Ligand-Target Pair