BDBM50037390 3-{(S)-2-(2-Carboxy-ethyl)-7-[3-(2-cyclopropylmethyl-3-methoxy-4-methylcarbamoyl-phenoxy)-propoxy]-chroman-8-yl}-propionic acid::3-{(S)-7-[3-(2-Cyclopropylmethyl-3-methoxy-4-methylcarbamoyl-phenoxy)-propoxy]-8-propyl-chroman-2-yl}-propionic acid::CHEMBL419948::SC-53228
SMILES: CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2CC[C@@H](CCC(O)=O)Oc12
InChI Key: InChIKey=YWYUQSGYKDEAMJ-QFIPXVFZSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Leukotriene B4 receptor (Homo sapiens (Human)) | BDBM50037390 (3-{(S)-2-(2-Carboxy-ethyl)-7-[3-(2-cyclopropylmeth...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]-LTB4. | J Med Chem 37: 3327-36 (1994) BindingDB Entry DOI: 10.7270/Q2HT2NC3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leukotriene B4 receptor (Homo sapiens (Human)) | BDBM50037390 (3-{(S)-2-(2-Carboxy-ethyl)-7-[3-(2-cyclopropylmeth...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Compound was tested for inhibitory activity against human neutrophil LTB4 receptor binding | J Med Chem 39: 2629-54 (1996) Article DOI: 10.1021/jm960088k BindingDB Entry DOI: 10.7270/Q21J9BFT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leukotriene B4 receptor (Homo sapiens (Human)) | BDBM50037390 (3-{(S)-2-(2-Carboxy-ethyl)-7-[3-(2-cyclopropylmeth...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against leukotriene B4 receptor | Bioorg Med Chem Lett 4: 811-816 (1994) Article DOI: 10.1016/S0960-894X(01)80853-2 BindingDB Entry DOI: 10.7270/Q2DN451X | |||||||||||
More data for this Ligand-Target Pair |