BDBM50038205 5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-benzoic acid methyl ester::CHEMBL131653

SMILES: COC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O

InChI Key: InChIKey=NOFICVMLKCZZHJ-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50038205   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50038205 (5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-benzoic ac...) Show SMILES COC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O Show InChI InChI=1S/C15H15NO5/c1-21-15(20)12-7-10(2-4-14(12)19)16-8-9-6-11(17)3-5-13(9)18/h2-7,16-19H,8H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
U266 INSERM-URA D1500 CNRS Curated by ChEMBL					Assay Description Inhibition of EGF-stimulated DNA synthesis in ER22 cells, by measuring [3H]Me-dT incorporation into ER 22 cells				J Med Chem 37: 845-59 (1994) BindingDB Entry DOI: 10.7270/Q2QV3KJ3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50038205 (5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-benzoic ac...) Show SMILES COC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O Show InChI InChI=1S/C15H15NO5/c1-21-15(20)12-7-10(2-4-14(12)19)16-8-9-6-11(17)3-5-13(9)18/h2-7,16-19H,8H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
U266 INSERM-URA D1500 CNRS Curated by ChEMBL					Assay Description Inhibitory potency against protein tyrosine kinase activity associated with EGFR was evaluated using ER 22 cell membrane				J Med Chem 37: 845-59 (1994) BindingDB Entry DOI: 10.7270/Q2QV3KJ3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50038205 (5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-benzoic ac...) Show SMILES COC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O Show InChI InChI=1S/C15H15NO5/c1-21-15(20)12-7-10(2-4-14(12)19)16-8-9-6-11(17)3-5-13(9)18/h2-7,16-19H,8H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of EGF-dependent DNA synthesis in ER 22 cells incubated with [3H]-TdR				J Med Chem 36: 4094-8 (1994) BindingDB Entry DOI: 10.7270/Q2KS6QMV
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50038205 (5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-benzoic ac...) Show SMILES COC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O Show InChI InChI=1S/C15H15NO5/c1-21-15(20)12-7-10(2-4-14(12)19)16-8-9-6-11(17)3-5-13(9)18/h2-7,16-19H,8H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.44E+4	n/a	n/a	n/a	n/a	n/a	n/a
SANDOZ Research Institute Curated by ChEMBL					Assay Description Inhibition of EGF-R Tyrosine kinase (TK)				J Med Chem 37: 4079-84 (1995) BindingDB Entry DOI: 10.7270/Q25D8QWP
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50038205 (5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-benzoic ac...) Show SMILES COC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O Show InChI InChI=1S/C15H15NO5/c1-21-15(20)12-7-10(2-4-14(12)19)16-8-9-6-11(17)3-5-13(9)18/h2-7,16-19H,8H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
U266 INSERM-URA D1500 CNRS Curated by ChEMBL					Assay Description Inhibition of EGFR(epidermal growth factor receptor) autophosphorylation in ER22 cell membranes				J Med Chem 37: 845-59 (1994) BindingDB Entry DOI: 10.7270/Q2QV3KJ3
					More data for this Ligand-Target Pair