BDBM50038907 1-(2,4-Difluoro-phenyl)-3-(6-methyl-4-o-tolyl-quinolin-3-yl)-urea::CHEMBL413330

SMILES: Cc1ccc2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3C)c2c1

InChI Key: InChIKey=KGNIGUDXLBHOOL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50038907   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sterol O-acyltransferase, Soat (Rattus norvegicus)	BDBM50038907 (1-(2,4-Difluoro-phenyl)-3-(6-methyl-4-o-tolyl-quin...) Show SMILES Cc1ccc2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3C)c2c1 |(3.34,-3.16,;4.67,-2.39,;4.67,-.84,;6,-.05,;7.35,-.84,;8.66,-.05,;10.01,-.82,;10.02,-2.36,;11.35,-3.13,;12.68,-2.36,;12.68,-.82,;14.02,-3.13,;14.03,-4.67,;12.7,-5.44,;12.7,-6.98,;14.05,-7.73,;14.05,-9.27,;15.38,-6.95,;15.36,-5.42,;16.69,-4.63,;8.69,-3.15,;8.69,-4.69,;10.03,-5.44,;10.02,-6.98,;8.69,-7.75,;7.35,-6.98,;7.35,-5.44,;6.02,-4.67,;7.35,-2.38,;6.02,-3.13,)| Show InChI InChI=1S/C24H19F2N3O/c1-14-7-9-20-18(11-14)23(17-6-4-3-5-15(17)2)22(13-27-20)29-24(30)28-21-10-8-16(25)12-19(21)26/h3-13H,1-2H3,(H2,28,29,30)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	21.7	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Chemical Industries, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes				J Med Chem 37: 2079-84 (1994) BindingDB Entry DOI: 10.7270/Q23F4NPC
					More data for this Ligand-Target Pair