BDBM50038922 1-(2,4-Difluoro-phenyl)-3-(6,8-dimethyl-4-o-tolyl-quinolin-3-yl)-urea::CHEMBL62876

SMILES: Cc1cc(C)c2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3C)c2c1

InChI Key: InChIKey=UESRUJSKPQNTAE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50038922   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sterol O-acyltransferase, Soat (Rattus norvegicus)	BDBM50038922 (1-(2,4-Difluoro-phenyl)-3-(6,8-dimethyl-4-o-tolyl-...) Show SMILES Cc1cc(C)c2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3C)c2c1 |(1.2,-4.35,;2.53,-3.57,;2.53,-2.03,;3.86,-1.24,;3.85,.3,;5.19,-2.01,;6.52,-1.24,;7.85,-2.01,;7.86,-3.55,;9.2,-4.32,;10.53,-3.55,;10.52,-2.01,;11.86,-4.3,;11.88,-5.84,;10.55,-6.61,;10.55,-8.15,;11.9,-8.92,;11.91,-10.46,;13.23,-8.13,;13.21,-6.6,;14.54,-5.82,;6.53,-4.32,;6.53,-5.86,;7.87,-6.63,;7.87,-8.15,;6.53,-8.94,;5.19,-8.17,;5.19,-6.63,;3.86,-5.86,;5.19,-3.55,;3.86,-4.32,)| Show InChI InChI=1S/C25H21F2N3O/c1-14-10-16(3)24-19(11-14)23(18-7-5-4-6-15(18)2)22(13-28-24)30-25(31)29-21-9-8-17(26)12-20(21)27/h4-13H,1-3H3,(H2,29,30,31)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Chemical Industries, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes				J Med Chem 37: 2079-84 (1994) BindingDB Entry DOI: 10.7270/Q23F4NPC
					More data for this Ligand-Target Pair