BDBM50039072 3-(5-Chloro-thiophen-2-yl)-6,7-dimethoxy-quinoline::CHEMBL69820
SMILES: COc1cc2cc(cnc2cc1OC)-c1ccc(Cl)s1
InChI Key: InChIKey=WOSBNMWHFVPOIW-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50039072 (3-(5-Chloro-thiophen-2-yl)-6,7-dimethoxy-quinoline...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer Central Research Curated by ChEMBL | Assay Description Concentration required to inhibit phosphorylation of isolated human epidermal growth factor tyrosine kinase receptor by 50% | J Med Chem 37: 2129-37 (1994) BindingDB Entry DOI: 10.7270/Q29Z93Z8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PDGFR-beta/Platelet-derived growth factor receptor alpha (Homo sapiens (Human)) | BDBM50039072 (3-(5-Chloro-thiophen-2-yl)-6,7-dimethoxy-quinoline...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer Central Research Curated by ChEMBL | Assay Description Inhibition of human PDGF receptor phosphorylation; 0.007-0.03 | J Med Chem 37: 2129-37 (1994) BindingDB Entry DOI: 10.7270/Q29Z93Z8 | |||||||||||
More data for this Ligand-Target Pair |