BDBM50040365 8-Amino-1,3-bis-cyclopropylmethyl-7-naphthalen-1-ylmethyl-3,7-dihydro-purine-2,6-dione::CHEMBL142969

SMILES: Nc1nc2n(CC3CC3)c(=O)n(CC3CC3)c(=O)c2n1Cc1cccc2ccccc12

InChI Key: InChIKey=MSNSVWMURXYFQD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50040365   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50040365 (8-Amino-1,3-bis-cyclopropylmethyl-7-naphthalen-1-y...) Show SMILES Nc1nc2n(CC3CC3)c(=O)n(CC3CC3)c(=O)c2n1Cc1cccc2ccccc12 Show InChI InChI=1S/C24H25N5O2/c25-23-26-21-20(27(23)14-18-6-3-5-17-4-1-2-7-19(17)18)22(30)29(13-16-10-11-16)24(31)28(21)12-15-8-9-15/h1-7,15-16H,8-14H2,(H2,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	9.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					Assay Description Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.				J Med Chem 37: 476-85 (1994) BindingDB Entry DOI: 10.7270/Q2P26X6N
					More data for this Ligand-Target Pair