BDBM50040370 CHEMBL145515::N'-(1,3-Bis-cyclopropylmethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-N,N-dimethyl-formamidine

SMILES: CN(C)C=Nc1nc2n(CC3CC3)c(=O)n(CC3CC3)c(=O)c2[nH]1

InChI Key: InChIKey=JVHGGXPKUOPZRZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50040370   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50040370 (CHEMBL145515 | N'-(1,3-Bis-cyclopropylmethyl-2,6-d...) Show SMILES CN(C)C=Nc1nc2n(CC3CC3)c(=O)n(CC3CC3)c(=O)c2[nH]1 |w:3.2| Show InChI InChI=1S/C16H22N6O2/c1-20(2)9-17-15-18-12-13(19-15)21(7-10-3-4-10)16(24)22(14(12)23)8-11-5-6-11/h9-11H,3-8H2,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					Assay Description Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM.				J Med Chem 37: 476-85 (1994) BindingDB Entry DOI: 10.7270/Q2P26X6N
					More data for this Ligand-Target Pair