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SMILES: OC(=O)[C@@H](NC(=O)C(Cc1ccc(cc1)-c1ccccc1)NCP(O)(O)=O)c1ccccc1

InChI Key: InChIKey=NUGZWZGJOFRYRK-KEKNWZKVSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50040401   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Rattus norvegicus (Rat))		BDBM50040401
PNG
((S)-[3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-pro...)
Show SMILES OC(=O)[C@@H](NC(=O)C(Cc1ccc(cc1)-c1ccccc1)NCP(O)(O)=O)c1ccccc1
Show InChI InChI=1S/C24H25N2O6P/c27-23(26-22(24(28)29)20-9-5-2-6-10-20)21(25-16-33(30,31)32)15-17-11-13-19(14-12-17)18-7-3-1-4-8-18/h1-14,21-22,25H,15-16H2,(H,26,27)(H,28,29)(H2,30,31,32)/t21?,22-/m0/s1
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Similars
PubMed
n/an/a 2n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
In vitro inhibition of Neutral endopeptidase (NEP) enzyme

J Med Chem 37: 498-511 (1994)


BindingDB Entry DOI: 10.7270/Q2H70GF9
More data for this
Ligand-Target Pair