Found 4 hits for monomerid = 50041072 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
MDM2-MDMX
(Homo sapiens (Human)) | BDBM50041072
(CHEMBL3355414)Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)[C@@H]1NC2(CCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:16.29,17.20,4.7,wD:10.10,1.0,(53.34,-24.73,;52.95,-26.21,;51.46,-26.61,;51.06,-28.11,;52.16,-29.18,;53.64,-28.78,;54.04,-27.3,;51.77,-30.67,;50.28,-31.08,;49.19,-29.99,;49.89,-32.57,;51.39,-32.89,;51.55,-34.41,;52.88,-35.18,;53.65,-33.85,;52.32,-33.09,;50.15,-35.05,;49.12,-33.91,;48.02,-32.81,;48.43,-31.31,;47.33,-30.21,;45.82,-30.61,;45.43,-32.12,;43.94,-32.53,;46.53,-33.21,;46.14,-34.7,;51.06,-36.31,;52.6,-36.3,;50.16,-37.57,;48.68,-37.1,;47.34,-37.87,;46.01,-37.1,;44.68,-37.86,;46.01,-35.55,;47.34,-34.78,;48.67,-35.55,)| Show InChI InChI=1S/C27H28Cl2FN3O3/c28-14-5-10-18-20(13-14)32-25(36)27(18)21(17-3-1-4-19(29)22(17)30)23(33-26(27)11-2-12-26)24(35)31-15-6-8-16(34)9-7-15/h1,3-5,10,13,15-16,21,23,33-34H,2,6-9,11-12H2,(H,31,35)(H,32,36)/t15-,16-,21-,23+,27+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
| Assay Description Inhibition of FAM-tagged p53-based PMDM6-F peptide binding to human recombinant His-tagged MDM2 (1 to 118 residues) after 30 mins by fluorescence pol... |
J Med Chem 60: 2819-2839 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01665 BindingDB Entry DOI: 10.7270/Q25Q4ZCF |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50041072
(CHEMBL3355414)Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)[C@@H]1NC2(CCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:16.29,17.20,4.7,wD:10.10,1.0,(53.34,-24.73,;52.95,-26.21,;51.46,-26.61,;51.06,-28.11,;52.16,-29.18,;53.64,-28.78,;54.04,-27.3,;51.77,-30.67,;50.28,-31.08,;49.19,-29.99,;49.89,-32.57,;51.39,-32.89,;51.55,-34.41,;52.88,-35.18,;53.65,-33.85,;52.32,-33.09,;50.15,-35.05,;49.12,-33.91,;48.02,-32.81,;48.43,-31.31,;47.33,-30.21,;45.82,-30.61,;45.43,-32.12,;43.94,-32.53,;46.53,-33.21,;46.14,-34.7,;51.06,-36.31,;52.6,-36.3,;50.16,-37.57,;48.68,-37.1,;47.34,-37.87,;46.01,-37.1,;44.68,-37.86,;46.01,-35.55,;47.34,-34.78,;48.67,-35.55,)| Show InChI InChI=1S/C27H28Cl2FN3O3/c28-14-5-10-18-20(13-14)32-25(36)27(18)21(17-3-1-4-19(29)22(17)30)23(33-26(27)11-2-12-26)24(35)31-15-6-8-16(34)9-7-15/h1,3-5,10,13,15-16,21,23,33-34H,2,6-9,11-12H2,(H,31,35)(H,32,36)/t15-,16-,21-,23+,27+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine
Curated by ChEMBL
| Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ... |
J Med Chem 57: 10486-98 (2014)
Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK |
More data for this Ligand-Target Pair | |
MDM2-MDMX
(Homo sapiens (Human)) | BDBM50041072
(CHEMBL3355414)Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)[C@@H]1NC2(CCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:16.29,17.20,4.7,wD:10.10,1.0,(53.34,-24.73,;52.95,-26.21,;51.46,-26.61,;51.06,-28.11,;52.16,-29.18,;53.64,-28.78,;54.04,-27.3,;51.77,-30.67,;50.28,-31.08,;49.19,-29.99,;49.89,-32.57,;51.39,-32.89,;51.55,-34.41,;52.88,-35.18,;53.65,-33.85,;52.32,-33.09,;50.15,-35.05,;49.12,-33.91,;48.02,-32.81,;48.43,-31.31,;47.33,-30.21,;45.82,-30.61,;45.43,-32.12,;43.94,-32.53,;46.53,-33.21,;46.14,-34.7,;51.06,-36.31,;52.6,-36.3,;50.16,-37.57,;48.68,-37.1,;47.34,-37.87,;46.01,-37.1,;44.68,-37.86,;46.01,-35.55,;47.34,-34.78,;48.67,-35.55,)| Show InChI InChI=1S/C27H28Cl2FN3O3/c28-14-5-10-18-20(13-14)32-25(36)27(18)21(17-3-1-4-19(29)22(17)30)23(33-26(27)11-2-12-26)24(35)31-15-6-8-16(34)9-7-15/h1,3-5,10,13,15-16,21,23,33-34H,2,6-9,11-12H2,(H,31,35)(H,32,36)/t15-,16-,21-,23+,27+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 149 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Comprehensive Cancer Center
Curated by ChEMBL
| Assay Description Evaluated for accumulation of cAMP in transfected HEK293 cells expressing human vasopressin V2 receptor |
J Med Chem 60: 2819-2839 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01665 BindingDB Entry DOI: 10.7270/Q25Q4ZCF |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50041072
(CHEMBL3355414)Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)[C@@H]1NC2(CCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:16.29,17.20,4.7,wD:10.10,1.0,(53.34,-24.73,;52.95,-26.21,;51.46,-26.61,;51.06,-28.11,;52.16,-29.18,;53.64,-28.78,;54.04,-27.3,;51.77,-30.67,;50.28,-31.08,;49.19,-29.99,;49.89,-32.57,;51.39,-32.89,;51.55,-34.41,;52.88,-35.18,;53.65,-33.85,;52.32,-33.09,;50.15,-35.05,;49.12,-33.91,;48.02,-32.81,;48.43,-31.31,;47.33,-30.21,;45.82,-30.61,;45.43,-32.12,;43.94,-32.53,;46.53,-33.21,;46.14,-34.7,;51.06,-36.31,;52.6,-36.3,;50.16,-37.57,;48.68,-37.1,;47.34,-37.87,;46.01,-37.1,;44.68,-37.86,;46.01,-35.55,;47.34,-34.78,;48.67,-35.55,)| Show InChI InChI=1S/C27H28Cl2FN3O3/c28-14-5-10-18-20(13-14)32-25(36)27(18)21(17-3-1-4-19(29)22(17)30)23(33-26(27)11-2-12-26)24(35)31-15-6-8-16(34)9-7-15/h1,3-5,10,13,15-16,21,23,33-34H,2,6-9,11-12H2,(H,31,35)(H,32,36)/t15-,16-,21-,23+,27+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 149 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine
Curated by ChEMBL
| Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ... |
J Med Chem 57: 10486-98 (2014)
Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK |
More data for this Ligand-Target Pair | |