BDBM50041076 CHEMBL3355419
SMILES: Fc1c(Cl)cccc1[C@H]1[C@@H](NC2(CCC2)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1
InChI Key: InChIKey=JGNVPNJDZXCHDI-AIUHUKMKSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MDM2-MDMX (Homo sapiens (Human)) | BDBM50041076 (CHEMBL3355419) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL | Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ... | J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MDM2-MDMX (Homo sapiens (Human)) | BDBM50041076 (CHEMBL3355419) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 9.52E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL | Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ... | J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK | |||||||||||
More data for this Ligand-Target Pair |