BDBM50041866 CHEMBL48017::N-(3,5-Dichloro-pyridin-4-yl)-3,4-dimethoxy-benzamide

SMILES: COc1ccc(cc1OC)C(=O)Nc1c(Cl)cncc1Cl

InChI Key: InChIKey=WFWCXZPAPUKWOC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50041866   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50041866 (CHEMBL48017 | N-(3,5-Dichloro-pyridin-4-yl)-3,4-di...) Show SMILES COc1ccc(cc1OC)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C14H12Cl2N2O3/c1-20-11-4-3-8(5-12(11)21-2)14(19)18-13-9(15)6-17-7-10(13)16/h3-7H,1-2H3,(H,17,18,19)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
LEO Pharma A/S Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMP				J Med Chem 57: 5893-903 (2014) Article DOI: 10.1021/jm500378a BindingDB Entry DOI: 10.7270/Q2CV4KC4
					More data for this Ligand-Target Pair
Phosphodiesterase 4A (Sus scrofa)	BDBM50041866 (CHEMBL48017 | N-(3,5-Dichloro-pyridin-4-yl)-3,4-di...) Show SMILES COc1ccc(cc1OC)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C14H12Cl2N2O3/c1-20-11-4-3-8(5-12(11)21-2)14(19)18-13-9(15)6-17-7-10(13)16/h3-7H,1-2H3,(H,17,18,19)	UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Central Research Curated by ChEMBL					Assay Description Inhibitory potency against pig aortic PDE IV				J Med Chem 37: 1696-703 (1994) BindingDB Entry DOI: 10.7270/Q2CF9P5F
					More data for this Ligand-Target Pair