BDBM50041963 CHEMBL24861::{2-Butyl-4-oxo-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3,4-dihydro-quinazolin-6-yl}-methyl-carbamic acid isobutyl ester::{2-Butyl-4-oxo-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3,4-dihydro-quinazolin-6-yl}-methyl-carbamic acid isobutyl ester

SMILES: CCCCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)N(C)C(=O)OCC(C)C

InChI Key: InChIKey=UCZOYWFJUMVFHA-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50041963   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Angiotensin II type 1a (AT-1a) receptor (RABBIT)	BDBM50041963 (CHEMBL24861 | {2-Butyl-4-oxo-3-[2'-(1H-tetrazol-5-...) Show SMILES CCCCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)N(C)C(=O)OCC(C)C Show InChI InChI=1S/C32H35N7O3/c1-5-6-11-29-33-28-17-16-24(38(4)32(41)42-20-21(2)3)18-27(28)31(40)39(29)19-22-12-14-23(15-13-22)25-9-7-8-10-26(25)30-34-36-37-35-30/h7-10,12-18,21H,5-6,11,19-20H2,1-4H3,(H,34,35,36,37)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Ability to displace [125I]-Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was dete...				Bioorg Med Chem Lett 3: 1299-1304 (1993) Article DOI: 10.1016/S0960-894X(00)80335-2 BindingDB Entry DOI: 10.7270/Q29P31KG
					More data for this Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor (RABBIT)	BDBM50041963 (CHEMBL24861 | {2-Butyl-4-oxo-3-[2'-(1H-tetrazol-5-...) Show SMILES CCCCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)N(C)C(=O)OCC(C)C Show InChI InChI=1S/C32H35N7O3/c1-5-6-11-29-33-28-17-16-24(38(4)32(41)42-20-21(2)3)18-27(28)31(40)39(29)19-22-12-14-23(15-13-22)25-9-7-8-10-26(25)30-34-36-37-35-30/h7-10,12-18,21H,5-6,11,19-20H2,1-4H3,(H,34,35,36,37)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Merck Pharmaceutical Company Curated by ChEMBL					Assay Description Inhibition of Angiotensin II receptor, type 1				J Med Chem 39: 625-56 (1996) Article DOI: 10.1021/jm9504722 BindingDB Entry DOI: 10.7270/Q29P3299
					More data for this Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor (RABBIT)	BDBM50041963 (CHEMBL24861 | {2-Butyl-4-oxo-3-[2'-(1H-tetrazol-5-...) Show SMILES CCCCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)N(C)C(=O)OCC(C)C Show InChI InChI=1S/C32H35N7O3/c1-5-6-11-29-33-28-17-16-24(38(4)32(41)42-20-21(2)3)18-27(28)31(40)39(29)19-22-12-14-23(15-13-22)25-9-7-8-10-26(25)30-34-36-37-35-30/h7-10,12-18,21H,5-6,11,19-20H2,1-4H3,(H,34,35,36,37)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [125I]-Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta				Bioorg Med Chem Lett 3: 1299-1304 (1993) Article DOI: 10.1016/S0960-894X(00)80335-2 BindingDB Entry DOI: 10.7270/Q29P31KG
					More data for this Ligand-Target Pair
Angiotensin II AT2 (RAT)	BDBM50041963 (CHEMBL24861 | {2-Butyl-4-oxo-3-[2'-(1H-tetrazol-5-...) Show SMILES CCCCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)N(C)C(=O)OCC(C)C Show InChI InChI=1S/C32H35N7O3/c1-5-6-11-29-33-28-17-16-24(38(4)32(41)42-20-21(2)3)18-27(28)31(40)39(29)19-22-12-14-23(15-13-22)25-9-7-8-10-26(25)30-34-36-37-35-30/h7-10,12-18,21H,5-6,11,19-20H2,1-4H3,(H,34,35,36,37)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA				J Med Chem 36: 3207-10 (1993) BindingDB Entry DOI: 10.7270/Q2QR4W6P
					More data for this Ligand-Target Pair
Angiotensin II AT2 (RAT)	BDBM50041963 (CHEMBL24861 | {2-Butyl-4-oxo-3-[2'-(1H-tetrazol-5-...) Show SMILES CCCCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)N(C)C(=O)OCC(C)C Show InChI InChI=1S/C32H35N7O3/c1-5-6-11-29-33-28-17-16-24(38(4)32(41)42-20-21(2)3)18-27(28)31(40)39(29)19-22-12-14-23(15-13-22)25-9-7-8-10-26(25)30-34-36-37-35-30/h7-10,12-18,21H,5-6,11,19-20H2,1-4H3,(H,34,35,36,37)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Merck Pharmaceutical Company Curated by ChEMBL					Assay Description Inhibitory activity at Angiotensin II type 2 receptor.				J Med Chem 39: 625-56 (1996) Article DOI: 10.1021/jm9504722 BindingDB Entry DOI: 10.7270/Q29P3299
					More data for this Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor (RABBIT)	BDBM50041963 (CHEMBL24861 | {2-Butyl-4-oxo-3-[2'-(1H-tetrazol-5-...) Show SMILES CCCCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)N(C)C(=O)OCC(C)C Show InChI InChI=1S/C32H35N7O3/c1-5-6-11-29-33-28-17-16-24(38(4)32(41)42-20-21(2)3)18-27(28)31(40)39(29)19-22-12-14-23(15-13-22)25-9-7-8-10-26(25)30-34-36-37-35-30/h7-10,12-18,21H,5-6,11,19-20H2,1-4H3,(H,34,35,36,37)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA				J Med Chem 36: 3207-10 (1993) BindingDB Entry DOI: 10.7270/Q2QR4W6P
					More data for this Ligand-Target Pair