BDBM50042260 1-[4'-(2-Butyl-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-biphenyl-2-yl]-2,2-dimethyl-propan-1-one::CHEMBL326049

SMILES: CCCCC1=NC2(CCCC2)CN1Cc1ccc(cc1)-c1ccccc1C(=O)C(C)(C)C

InChI Key: InChIKey=DYURUOUOBVIGCU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50042260   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Angiotensin II AT1B (RAT)	BDBM50042260 (1-[4'-(2-Butyl-1,3-diaza-spiro[4.4]non-1-en-3-ylme...) Show SMILES CCCCC1=NC2(CCCC2)CN1Cc1ccc(cc1)-c1ccccc1C(=O)C(C)(C)C |t:4| Show InChI InChI=1S/C29H38N2O/c1-5-6-13-26-30-29(18-9-10-19-29)21-31(26)20-22-14-16-23(17-15-22)24-11-7-8-12-25(24)27(32)28(2,3)4/h7-8,11-12,14-17H,5-6,9-10,13,18-21H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi Recherche Curated by ChEMBL					Assay Description Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membran...				J Med Chem 36: 3371-80 (1993) BindingDB Entry DOI: 10.7270/Q22Z14M0
					More data for this Ligand-Target Pair