BDBM50042634 (E)-(3R,5S)-7-[2-Dimethylamino-4,5-bis-(4-fluoro-phenyl)-imidazol-1-yl]-3,5-dihydroxy-hept-6-enoic acid anion::CHEMBL123127::Sodium; 7-[2-dimethylamino-4,5-bis-(4-fluoro-phenyl)-imidazol-1-yl]-3,5-dihydroxy-hept-6-enoate

SMILES: CN(C)c1nc(c(-c2ccc(F)cc2)n1\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)-c1ccc(F)cc1

InChI Key: InChIKey=GVZUOJWJKSNJNR-XICOBVEKSA-M

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50042634   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) (Homo sapiens (Human))	BDBM50042634 ((E)-(3R,5S)-7-[2-Dimethylamino-4,5-bis-(4-fluoro-p...) Show SMILES CN(C)c1nc(c(-c2ccc(F)cc2)n1\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)-c1ccc(F)cc1 Show InChI InChI=1S/C24H25F2N3O4/c1-28(2)24-27-22(15-3-7-17(25)8-4-15)23(16-5-9-18(26)10-6-16)29(24)12-11-19(30)13-20(31)14-21(32)33/h3-12,19-20,30-31H,13-14H2,1-2H3,(H,32,33)/p-1/b12-11+/t19-,20-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.04	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Pharmaceutical Education and Research (NIPER) Curated by ChEMBL					Assay Description Inhibitory concentration against 3-hydroxy-3-methylglutaryl-CoA reductase				Bioorg Med Chem Lett 15: 1027-32 (2005) Article DOI: 10.1016/j.bmcl.2004.12.042 BindingDB Entry DOI: 10.7270/Q2TB17N9
					More data for this Ligand-Target Pair
HMG-CoA reductase (Rattus norvegicus (rat))	BDBM50042634 ((E)-(3R,5S)-7-[2-Dimethylamino-4,5-bis-(4-fluoro-p...) Show SMILES CN(C)c1nc(c(-c2ccc(F)cc2)n1\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)-c1ccc(F)cc1 Show InChI InChI=1S/C24H25F2N3O4/c1-28(2)24-27-22(15-3-7-17(25)8-4-15)23(16-5-9-18(26)10-6-16)29(24)12-11-19(30)13-20(31)14-21(32)33/h3-12,19-20,30-31H,13-14H2,1-2H3,(H,32,33)/p-1/b12-11+/t19-,20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Group Research Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)				J Med Chem 36: 3646-57 (1994) BindingDB Entry DOI: 10.7270/Q2X929CH
					More data for this Ligand-Target Pair