BDBM50042638 (E)-(3R,5S)-7-[5-(3,5-Dimethyl-phenyl)-4-(4-fluoro-phenyl)-2-isopropyl-imidazol-1-yl]-3,5-dihydroxy-hept-6-enoic acid anion::CHEMBL122725::Sodium; 7-[5-(3,5-dimethyl-phenyl)-4-(4-fluoro-phenyl)-2-isopropyl-imidazol-1-yl]-3,5-dihydroxy-hept-6-enoate

SMILES: CC(C)c1nc(c(-c2cc(C)cc(C)c2)n1\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)-c1ccc(F)cc1

InChI Key: InChIKey=LYUVRKOESGKHFS-GZURJRJYSA-M

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50042638   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) (Homo sapiens (Human))	BDBM50042638 ((E)-(3R,5S)-7-[5-(3,5-Dimethyl-phenyl)-4-(4-fluoro...) Show SMILES CC(C)c1nc(c(-c2cc(C)cc(C)c2)n1\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)-c1ccc(F)cc1 Show InChI InChI=1S/C27H31FN2O4/c1-16(2)27-29-25(19-5-7-21(28)8-6-19)26(20-12-17(3)11-18(4)13-20)30(27)10-9-22(31)14-23(32)15-24(33)34/h5-13,16,22-23,31-32H,14-15H2,1-4H3,(H,33,34)/p-1/b10-9+/t22-,23-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.25	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Pharmaceutical Education and Research (NIPER) Curated by ChEMBL					Assay Description Inhibitory concentration against 3-hydroxy-3-methylglutaryl-CoA reductase				Bioorg Med Chem Lett 15: 1027-32 (2005) Article DOI: 10.1016/j.bmcl.2004.12.042 BindingDB Entry DOI: 10.7270/Q2TB17N9
					More data for this Ligand-Target Pair
HMG-CoA reductase (Rattus norvegicus (rat))	BDBM50042638 ((E)-(3R,5S)-7-[5-(3,5-Dimethyl-phenyl)-4-(4-fluoro...) Show SMILES CC(C)c1nc(c(-c2cc(C)cc(C)c2)n1\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)-c1ccc(F)cc1 Show InChI InChI=1S/C27H31FN2O4/c1-16(2)27-29-25(19-5-7-21(28)8-6-19)26(20-12-17(3)11-18(4)13-20)30(27)10-9-22(31)14-23(32)15-24(33)34/h5-13,16,22-23,31-32H,14-15H2,1-4H3,(H,33,34)/p-1/b10-9+/t22-,23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Group Research Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)				J Med Chem 36: 3646-57 (1994) BindingDB Entry DOI: 10.7270/Q2X929CH
					More data for this Ligand-Target Pair