BDBM50042726 4-Amino-5-chloro-N-[1-(4-fluoro-benzyl)-piperidin-4-yl]-2-methoxy-benzamide::CHEMBL125237
SMILES: COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccc(F)cc2)CC1
InChI Key: InChIKey=HKDIGEWWDHALIS-UHFFFAOYSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50042726 (4-Amino-5-chloro-N-[1-(4-fluoro-benzyl)-piperidin-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.950 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania Curated by ChEMBL | Assay Description Inhibition of [125I]- NCQ 298 binding to D2 receptor of rat striatal tissue | J Med Chem 36: 3707-20 (1994) BindingDB Entry DOI: 10.7270/Q2MK6DH1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50042726 (4-Amino-5-chloro-N-[1-(4-fluoro-benzyl)-piperidin-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 283 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania Curated by ChEMBL | Assay Description In vitro binding affinity on 5-hydroxytryptamine 2 receptor is inhibition of binding of [125I]- I-LSD to P11 cells | J Med Chem 36: 3707-20 (1994) BindingDB Entry DOI: 10.7270/Q2MK6DH1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50042726 (4-Amino-5-chloro-N-[1-(4-fluoro-benzyl)-piperidin-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania Curated by ChEMBL | Assay Description In vitro binding affinity on alpha-2 receptor is inhibition of binding of [3H]- rauwolscine to rat cortex | J Med Chem 36: 3707-20 (1994) BindingDB Entry DOI: 10.7270/Q2MK6DH1 | |||||||||||
More data for this Ligand-Target Pair |