BindingDB PrimarySearch

BDBM50042944 (E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-propenone::(E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one::1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-propenone::1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-prop-2-en-1-one::1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one::2',4',4-trihydroxychalcone::2',4,4'-trihydroxychalcone::2,4'-dihydroxy-4-hydroxychalcone::CHEMBL129795::Isoliquiritigenin (1)::cid_638278

SMILES: Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1

InChI Key: InChIKey=DXDRHHKMWQZJHT-FPYGCLRLSA-N

Data: 32 IC50 3 EC50

PDB links: 5 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 35 hits for monomerid = 50042944
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Bcl-2-like protein 11 (Homo sapiens (Human))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	n/a	>3.50E+5	n/a	n/a	n/a	n/a
Broad Institute Curated by PubChem BioAssay					Assay Description Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q24J0CKJ
Broad Institute Curated by PubChem BioAssay					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	5.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of TDP1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using 5'-FAM-AGGATCTAAAAGACTT-BHQ-3' as substrate preincubated for 30 mi...				Bioorg Med Chem 28: (2020)
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.30E+4	n/a	n/a	n/a	n/a	4.5	37
Shanghai Institute of Materia Medica, Chinese Academy of Sciences					Assay Description The assay based on fluorescenceresonance energy transfer was carried out with BACE1 enzyme at pH 4.5 with a substrate, H-Lys(DABSYL)-SEVNLDAEFR-Gin-(...				J Enzyme Inhib Med Chem 26: 643-8 (2011) Article DOI: 10.3109/14756366.2010.543420 BindingDB Entry DOI: 10.7270/Q2DR2TCJ
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tokushima Bunri University Curated by ChEMBL					Assay Description In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined				J Med Chem 36: 3904-9 (1994) BindingDB Entry DOI: 10.7270/Q2MS3RT4
Tokushima Bunri University Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit (Homo sapiens (Human))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.16E+4	n/a	n/a	n/a	n/a
Instituto de Qu£mica M£dica (IQM-CSIC) Curated by ChEMBL					Assay Description Positive allosteric modulation at human alpha7 nACHR expressed in Xenopus oocyte assessed as potentiation of 200 uM ACh-induced current at holding po...				Eur J Med Chem 86: 724-39 (2014) Article DOI: 10.1016/j.ejmech.2014.09.039 BindingDB Entry DOI: 10.7270/Q2PN977T
Instituto de Qu£mica M£dica (IQM-CSIC) Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (AR) (Homo sapiens (Human))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
King's College London Curated by ChEMBL					Assay Description Inhibition of human recombinant aldose reductase using D-glyceraldehyde as substrate preincubated for 10 mins before substrate addition measured for ...				Bioorg Med Chem 20: 1251-8 (2012) Article DOI: 10.1016/j.bmc.2011.12.033 BindingDB Entry DOI: 10.7270/Q2639Q5V
King's College London Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Roma"La Sapienza" Curated by ChEMBL					Assay Description Compound concentration required to reduce HIV-1 Integrase 3'-processing activity by 50%				J Med Chem 41: 3948-60 (1998) Article DOI: 10.1021/jm9707232 BindingDB Entry DOI: 10.7270/Q29024G3
Universit£ di Roma"La Sapienza" Curated by ChEMBL					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of 5-lipoxygenase in rat RBL1 cells				Citation and Details Article DOI: 10.1007/s00044-013-0745-7 BindingDB Entry DOI: 10.7270/Q22N53QB
TBA					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (Homo sapiens (Human))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute Curated by ChEMBL					Assay Description Inhibition of recombinant human PTP1B assessed as hydrolysis of p-nitrophenyl phosphate after 30 mins				Bioorg Med Chem Lett 19: 5155-7 (2009) Article DOI: 10.1016/j.bmcl.2009.07.054 BindingDB Entry DOI: 10.7270/Q24X58R7
Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (Homo sapiens (Human))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Bioscience and Biotechnology Curated by ChEMBL					Assay Description Inhibition of human recombinant PTP1B				J Nat Prod 69: 1572-6 (2006) Article DOI: 10.1021/np0601861 BindingDB Entry DOI: 10.7270/Q2B8591J
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Tennessee Health Science Center Curated by ChEMBL					Assay Description Inhibitory activity against HIV-1 Integrase (HIV-1-IN)				J Med Chem 45: 841-52 (2002) BindingDB Entry DOI: 10.7270/Q28W3FGV
					More data for this Ligand-Target Pair
Monoamine oxidase (Rattus norvegicus (rat))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.73E+4	n/a	n/a	n/a	n/a	n/a	n/a
North-West University Curated by ChEMBL					Assay Description Inhibition of Wistar rat liver mitochondrial MAO-A using benzylamine hydrochloride as substrate after 1 hr by spectrophotometric analysis				Bioorg Med Chem Lett 26: 4599-4605 (2016) Article DOI: 10.1016/j.bmcl.2016.08.067 BindingDB Entry DOI: 10.7270/Q2CC12M3
North-West University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclooxygenase (Homo sapiens (Human))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	1.30E+5	n/a	n/a	n/a	n/a	n/a	n/a
Tokushima Bunri University Curated by ChEMBL					Assay Description Inhibition of Prostaglandin G/H synthase activity in sheep seminal vesicle was determined 100 uM				J Med Chem 36: 3904-9 (1994) BindingDB Entry DOI: 10.7270/Q2MS3RT4
Tokushima Bunri University Curated by ChEMBL					More data for this Ligand-Target Pair
Xanthine dehydrogenase (Bos taurus (Bovine))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.73E+4	n/a	n/a	n/a	n/a	n/a	n/a
Guangxi Medical University Curated by ChEMBL					Assay Description Inhibition of bovine milk xanthine oxidase pre-incubated for 30 mins followed by xanthine addition and measured every 30 secs for 5 mins by spectroph...				Bioorg Med Chem Lett 27: 3602-3606 (2017) Article DOI: 10.1016/j.bmcl.2017.01.053 BindingDB Entry DOI: 10.7270/Q2F76G1K
Guangxi Medical University Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.15E+4	n/a	n/a	n/a	n/a	n/a	n/a
Ewha Womans University Curated by ChEMBL					Assay Description Ability to displace [3H]quipazine binding to 5-hydroxytryptamine 3 receptor sites in NG 108-15.				Bioorg Med Chem Lett 27: 3123-3126 (2017) Article DOI: 10.1016/j.bmcl.2017.05.035 BindingDB Entry DOI: 10.7270/Q2QR50K7
Ewha Womans University Curated by ChEMBL					More data for this Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 2 (Homo sapiens (Human))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
University of Basel Curated by ChEMBL					Assay Description Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation countin...				J Nat Prod 80: 965-974 (2017) Article DOI: 10.1021/acs.jnatprod.6b00950 BindingDB Entry DOI: 10.7270/Q2XD148R
University of Basel Curated by ChEMBL					More data for this Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 1 (Homo sapiens (Human))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.83E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Basel Curated by ChEMBL					Assay Description Inhibition of human 17beta-HSD1 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estrone and NADPH by scintillation counting...				J Nat Prod 80: 965-974 (2017) Article DOI: 10.1021/acs.jnatprod.6b00950 BindingDB Entry DOI: 10.7270/Q2XD148R
University of Basel Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 19A1 (Homo sapiens (Human))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Basel Curated by ChEMBL					Assay Description Inhibition of aromatase (unknown origin)				J Nat Prod 80: 965-974 (2017) Article DOI: 10.1021/acs.jnatprod.6b00950 BindingDB Entry DOI: 10.7270/Q2XD148R
University of Basel Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.87E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Basel Curated by ChEMBL					Assay Description Displacement of estradiol from human ERalpha expressed in yeast cells				J Nat Prod 80: 965-974 (2017) Article DOI: 10.1021/acs.jnatprod.6b00950 BindingDB Entry DOI: 10.7270/Q2XD148R
University of Basel Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	269	n/a	n/a	n/a	n/a	n/a	n/a
University of Basel Curated by ChEMBL					Assay Description Displacement of estradiol from human ERbetaa expressed in yeast cells				J Nat Prod 80: 965-974 (2017) Article DOI: 10.1021/acs.jnatprod.6b00950 BindingDB Entry DOI: 10.7270/Q2XD148R
University of Basel Curated by ChEMBL					More data for this Ligand-Target Pair
NLRP3 protein (Homo sapiens (Human))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.54E+3	n/a	n/a	n/a	n/a	n/a	n/a
Soochow University Curated by ChEMBL					Assay Description Inhibition of NLRP3 inflammasome in human THP1 cells assessed as reduction in MSU-induced IL-1beta production preincubated for 1 hr followed by MSU s...				Bioorg Med Chem 26: 1653-1664 (2018) Article DOI: 10.1016/j.bmc.2018.02.013 BindingDB Entry DOI: 10.7270/Q2QZ2DK4
Soochow University Curated by ChEMBL					More data for this Ligand-Target Pair
Neuraminidase (Influenza A virus)	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.32E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chosun University Curated by ChEMBL					Assay Description Inhibition of oseltamivir-resistant H1N1 swine influenza virus neuraminidase H274Y mutant activity expressed in HEK293T cells after 2 hrs by spectrof...				Bioorg Med Chem Lett 21: 294-8 (2011) Article DOI: 10.1016/j.bmcl.2010.11.016 BindingDB Entry DOI: 10.7270/Q2N87DMZ
Chosun University Curated by ChEMBL					More data for this Ligand-Target Pair
Neuraminidase (Influenza A virus)	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.78E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chosun University Curated by ChEMBL					Assay Description Inhibition of Influenza A H9N2 virus neuraminidase activity after 2 hrs by spectrofluorometry				Bioorg Med Chem Lett 21: 294-8 (2011) Article DOI: 10.1016/j.bmcl.2010.11.016 BindingDB Entry DOI: 10.7270/Q2N87DMZ
Chosun University Curated by ChEMBL					More data for this Ligand-Target Pair
Neuraminidase (Influenza A virus)	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.29E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chosun University Curated by ChEMBL					Assay Description Noncompetitive inhibition of Influenza A H1N1 virus neuraminidase activity by Lineweaver-Burk plot analysis				Bioorg Med Chem Lett 21: 294-8 (2011) Article DOI: 10.1016/j.bmcl.2010.11.016 BindingDB Entry DOI: 10.7270/Q2N87DMZ
Chosun University Curated by ChEMBL					More data for this Ligand-Target Pair
Neuraminidase (Influenza A virus)	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.27E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chosun University Curated by ChEMBL					Assay Description Inhibition of Influenza A H1N1 virus neuraminidase activity after 2 hrs by spectrofluorometry				Bioorg Med Chem Lett 21: 294-8 (2011) Article DOI: 10.1016/j.bmcl.2010.11.016 BindingDB Entry DOI: 10.7270/Q2N87DMZ
Chosun University Curated by ChEMBL					More data for this Ligand-Target Pair
Sialidase (Clostridium perfringens)	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.29E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chosun University Curated by ChEMBL					Assay Description Inhibition of Clostridium perfringens neuraminidase				Bioorg Med Chem Lett 21: 294-8 (2011) Article DOI: 10.1016/j.bmcl.2010.11.016 BindingDB Entry DOI: 10.7270/Q2N87DMZ
Chosun University Curated by ChEMBL					More data for this Ligand-Target Pair
Neuraminidase (Influenza A virus)	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.36E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chosun University Curated by ChEMBL					Assay Description Inhibition of wild type H1N1 swine influenza virus neuraminidase activity expressed in HEK293T cells after 2 hrs by spectrofluorometry				Bioorg Med Chem Lett 21: 294-8 (2011) Article DOI: 10.1016/j.bmcl.2010.11.016 BindingDB Entry DOI: 10.7270/Q2N87DMZ
Chosun University Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	3.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of BACE1 (unknown origin)				Citation and Details Article DOI: 10.1007/s00044-012-0353-y BindingDB Entry DOI: 10.7270/Q29Z97T4
TBA					More data for this Ligand-Target Pair
Aldose reductase (Rattus norvegicus)	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Rattus norvegicus (rat) lens aldose reductase				Citation and Details Article DOI: 10.1007/s00044-012-0367-5 BindingDB Entry DOI: 10.7270/Q2XP77VN
TBA					More data for this Ligand-Target Pair
Monoamine oxidase (Rattus norvegicus (rat))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.72E+4	n/a	n/a	n/a	n/a	n/a	n/a
North-West University Curated by ChEMBL					Assay Description Displacement of [14C]-beta-PEA from rat MAO-B after 20 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 23: 4985-9 (2013) Article DOI: 10.1016/j.bmcl.2013.06.050 BindingDB Entry DOI: 10.7270/Q29K4F4Z
North-West University Curated by ChEMBL					More data for this Ligand-Target Pair
Monoamine oxidase (Rattus norvegicus (rat))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.39E+4	n/a	n/a	n/a	n/a	n/a	n/a
North-West University Curated by ChEMBL					Assay Description Displacement of [14C]-5HT from rat MAO-A after 20 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 23: 4985-9 (2013) Article DOI: 10.1016/j.bmcl.2013.06.050 BindingDB Entry DOI: 10.7270/Q29K4F4Z
North-West University Curated by ChEMBL					More data for this Ligand-Target Pair
Beta amyloid A4 protein (Homo sapiens (Human))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.97E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of amyloid beta (1-42) self-mediated aggregation (unknown origin) after 5 days by thioflavin T fluorescence method				Eur J Med Chem 66: 22-31 (2013) Article DOI: 10.1016/j.ejmech.2013.05.015 BindingDB Entry DOI: 10.7270/Q2GF0XFF
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
Proteasome subunit beta type-1/beta type-5 (Homo sapiens (Human))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Agricultural and Food Biotechnology Curated by ChEMBL					Assay Description Inhibition of chymotrypsin-like activity of purified human erythrocyte 20S proteasome assessed as decrease in AMC hydrolysis using Suc-LLVY-AMC as su...				Eur J Med Chem 167: 291-311 (2019) Article DOI: 10.1016/j.ejmech.2019.01.044
					More data for this Ligand-Target Pair
NLRP3 protein (Homo sapiens (Human))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	1.01E+4	n/a	n/a	n/a	n/a	n/a	n/a
Soochow University Curated by ChEMBL					Assay Description Inhibition of NLRP3 in human THP1 cells assessed as inhibition of MSU-induced IL-1beta production				Bioorg Med Chem Lett 30: (2020)
Soochow University Curated by ChEMBL					More data for this Ligand-Target Pair
Probable global transcription activator SNF2L2 (Homo sapiens (Human))	BDBM50042944 ((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	n/a	9.11E+4	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay									PubChem Bioassay (2013) BindingDB Entry DOI: 10.7270/Q2GF0S4R
					More data for this Ligand-Target Pair