BDBM50042976 (E)-3-Phenyl-1-(2,4,6-trihydroxy-phenyl)-propenone::(E)-3-phenyl-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one::2',4',6'-trihydroxychalcone::3-Phenyl-1-(2,4,6-trihydroxy-phenyl)-propenone::CHEMBL129371
SMILES: Oc1cc(O)c(C(=O)\C=C\c2ccccc2)c(O)c1
InChI Key: InChIKey=LOYXTWZXLWHMBX-VOTSOKGWSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Arachidonate 5-lipoxygenase (Rattus norvegicus) | BDBM50042976 ((E)-3-Phenyl-1-(2,4,6-trihydroxy-phenyl)-propenone...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.40E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokushima Bunri University Curated by ChEMBL | Assay Description In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined | J Med Chem 36: 3904-9 (1994) BindingDB Entry DOI: 10.7270/Q2MS3RT4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosinase (Agaricus bisporus (Common mushroom)) | BDBM50042976 ((E)-3-Phenyl-1-(2,4,6-trihydroxy-phenyl)-propenone...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokkaido University Curated by ChEMBL | Assay Description Inhibition of mushroom tyrosinase | Bioorg Med Chem 15: 2396-402 (2007) Article DOI: 10.1016/j.bmc.2007.01.017 BindingDB Entry DOI: 10.7270/Q2R78DWH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/glucose cotransporter 1 (SGLT1) (Homo sapiens (Human)) | BDBM50042976 ((E)-3-Phenyl-1-(2,4,6-trihydroxy-phenyl)-propenone...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.54E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade de Lisboa Curated by ChEMBL | Assay Description Inhibition of human SGLT1 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose ... | J Med Chem 60: 568-579 (2017) Article DOI: 10.1021/acs.jmedchem.6b01134 BindingDB Entry DOI: 10.7270/Q2KK9F2F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/glucose cotransporter 2 (Homo sapiens (Human)) | BDBM50042976 ((E)-3-Phenyl-1-(2,4,6-trihydroxy-phenyl)-propenone...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.33E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade de Lisboa Curated by ChEMBL | Assay Description Inhibition of human SGLT2 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose ... | J Med Chem 60: 568-579 (2017) Article DOI: 10.1021/acs.jmedchem.6b01134 BindingDB Entry DOI: 10.7270/Q2KK9F2F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Arachidonate 5-lipoxygenase (Rattus norvegicus) | BDBM50042976 ((E)-3-Phenyl-1-(2,4,6-trihydroxy-phenyl)-propenone...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article | n/a | n/a | 1.40E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of 5-lipoxygenase in rat RBL1 cells | Citation and Details Article DOI: 10.1007/s00044-013-0745-7 BindingDB Entry DOI: 10.7270/Q22N53QB | |||||||||||
More data for this Ligand-Target Pair |