null

SMILES: COc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(C)ccc2F)cc1

InChI Key: InChIKey=FZDJPIKBPRASNV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50043021   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM50043021 (CHEMBL3355031 | US9718825, Example 140) Show SMILES COc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(C)ccc2F)cc1 Show InChI InChI=1S/C19H16FN5O3S/c1-11-3-8-15(20)16(9-11)29(26,27)25-13-6-4-12(5-7-13)17-22-18-14(10-21-24-18)19(23-17)28-2/h3-10,25H,1-2H3,(H,21,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Inhibition of SGK1 (unknown origin) assessed as substrate phosphorylation				ACS Med Chem Lett 6: 19-20 (2015) Article DOI: 10.1021/ml500480n BindingDB Entry DOI: 10.7270/Q2PZ5BFB
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM50043021 (CHEMBL3355031 | US9718825, Example 140) Show SMILES COc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(C)ccc2F)cc1 Show InChI InChI=1S/C19H16FN5O3S/c1-11-3-8-15(20)16(9-11)29(26,27)25-13-6-4-12(5-7-13)17-22-18-14(10-21-24-18)19(23-17)28-2/h3-10,25H,1-2H3,(H,21,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.4	n/a
SANOFI US Patent					Assay Description The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...				US Patent US9718825 (2017) BindingDB Entry DOI: 10.7270/Q2VM4F82
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM50043021 (CHEMBL3355031 | US9718825, Example 140) Show SMILES COc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(C)ccc2F)cc1 Show InChI InChI=1S/C19H16FN5O3S/c1-11-3-8-15(20)16(9-11)29(26,27)25-13-6-4-12(5-7-13)17-22-18-14(10-21-24-18)19(23-17)28-2/h3-10,25H,1-2H3,(H,21,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	7.4	n/a
SANOFI US Patent					Assay Description The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...				US Patent US9718825 (2017) BindingDB Entry DOI: 10.7270/Q2VM4F82
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM50043021 (CHEMBL3355031 | US9718825, Example 140) Show SMILES COc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(C)ccc2F)cc1 Show InChI InChI=1S/C19H16FN5O3S/c1-11-3-8-15(20)16(9-11)29(26,27)25-13-6-4-12(5-7-13)17-22-18-14(10-21-24-18)19(23-17)28-2/h3-10,25H,1-2H3,(H,21,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Inhibition of recombinant SGK1 (unknown origin) expressed in U2OS cells by cellular activity assay				ACS Med Chem Lett 6: 19-20 (2015) Article DOI: 10.1021/ml500480n BindingDB Entry DOI: 10.7270/Q2PZ5BFB
					More data for this Ligand-Target Pair