null

SMILES: CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)c2ccc(Cl)c(Cl)c2)c(F)c1

InChI Key: InChIKey=UVGNUQSLESLFEA-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50044248   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM50044248 (CHEMBL3314035 | US9216988, 98) Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)c2ccc(Cl)c(Cl)c2)c(F)c1 Show InChI InChI=1S/C23H26Cl2FN3O3S/c1-16(30)27-9-11-28(12-10-27)19-6-5-17(23(26)13-19)15-29(18-3-2-4-18)33(31,32)20-7-8-21(24)22(25)14-20/h5-8,13-14,18H,2-4,9-12,15H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of [3H2]25-hydroxycholesterol from RoRc-LBD (unknown origin)				J Med Chem 57: 5871-92 (2014) Article DOI: 10.1021/jm401901d BindingDB Entry DOI: 10.7270/Q2M0473Z
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM50044248 (CHEMBL3314035 | US9216988, 98) Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)c2ccc(Cl)c(Cl)c2)c(F)c1 Show InChI InChI=1S/C23H26Cl2FN3O3S/c1-16(30)27-9-11-28(12-10-27)19-6-5-17(23(26)13-19)15-29(18-3-2-4-18)33(31,32)20-7-8-21(24)22(25)14-20/h5-8,13-14,18H,2-4,9-12,15H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	n/a
Genentech, Inc. US Patent					Assay Description On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...				US Patent US9216988 (2015) BindingDB Entry DOI: 10.7270/Q2TB15QC
					More data for this Ligand-Target Pair