BDBM50044348 5-Butyl-2-(2-oxo-2-phenyl-ethyl)-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2,4-dihydro-[1,2,4]triazol-3-one::5-Butyl-2-(2-oxo-2-phenyl-ethyl)-4-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2,4-dihydro-[1,2,4]triazol-3-one::CHEMBL87942
SMILES: CCCCc1nn(CC(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
InChI Key: InChIKey=SLLKEOIZGYGZBQ-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Type-1 angiotensin II receptor (RABBIT) | BDBM50044348 (5-Butyl-2-(2-oxo-2-phenyl-ethyl)-4-[2'-(1H-tetrazo...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without usi... | J Med Chem 36: 2558-68 (1993) BindingDB Entry DOI: 10.7270/Q2KP817C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1A/Type-1B angiotensin II receptor (RAT) | BDBM50044348 (5-Butyl-2-(2-oxo-2-phenyl-ethyl)-4-[2'-(1H-tetrazo...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [125I]-angiotensin 2 from angiotensin AT1 receptor in Rattus norvegicus (rat) uterine membranes | Citation and Details Article DOI: 10.1007/s00044-011-9622-4 BindingDB Entry DOI: 10.7270/Q2T156HH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1A/Type-1B angiotensin II receptor (RAT) | BDBM50044348 (5-Butyl-2-(2-oxo-2-phenyl-ethyl)-4-[2'-(1H-tetrazo...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [125I]-angiotensin 2 from angiotensin AT1 receptor in Rattus norvegicus (rat) uterine membranes | Citation and Details Article DOI: 10.1007/s00044-011-9622-4 BindingDB Entry DOI: 10.7270/Q2T156HH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1B angiotensin II receptor (RAT) | BDBM50044348 (5-Butyl-2-(2-oxo-2-phenyl-ethyl)-4-[2'-(1H-tetrazo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Searle R&D Curated by ChEMBL | Assay Description Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes | J Med Chem 36: 2172-81 (1993) BindingDB Entry DOI: 10.7270/Q2C53JXM | |||||||||||
More data for this Ligand-Target Pair |