BDBM50044464 CHEMBL3357459

SMILES: CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CCN(CC3)C(=O)CO)c2)ncc1Cl

InChI Key: InChIKey=YRQIZIMDOXXDDC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50044464   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50044464 (CHEMBL3357459) Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CCN(CC3)C(=O)CO)c2)ncc1Cl Show InChI InChI=1S/C27H32ClN7O5S/c1-18(2)41(39,40)23-9-4-3-8-22(23)32-26-21(28)15-29-27(33-26)31-20-7-5-6-19(14-20)30-24(37)16-34-10-12-35(13-11-34)25(38)17-36/h3-9,14-15,18,36H,10-13,16-17H2,1-2H3,(H,30,37)(H2,29,31,32,33)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of ALK (unknown origin) after 60 mins by ELISA				J Med Chem 58: 197-211 (2015) Article DOI: 10.1021/jm5005144 BindingDB Entry DOI: 10.7270/Q2FB54MQ
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50044464 (CHEMBL3357459) Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CCN(CC3)C(=O)CO)c2)ncc1Cl Show InChI InChI=1S/C27H32ClN7O5S/c1-18(2)41(39,40)23-9-4-3-8-22(23)32-26-21(28)15-29-27(33-26)31-20-7-5-6-19(14-20)30-24(37)16-34-10-12-35(13-11-34)25(38)17-36/h3-9,14-15,18,36H,10-13,16-17H2,1-2H3,(H,30,37)(H2,29,31,32,33)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	338	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA				J Med Chem 58: 197-211 (2015) Article DOI: 10.1021/jm5005144 BindingDB Entry DOI: 10.7270/Q2FB54MQ
					More data for this Ligand-Target Pair