BDBM50045092 5-(2-Carboxy-ethyl)-6-[(E)-6-(4-methoxy-phenyl)-hex-5-enyloxy]-9-oxo-9H-xanthene-2-carboxylic acid::5-(2-Carboxy-ethyl)-6-[6-(4-methoxy-phenyl)-hex-5-enyloxy]-9-oxo-9H-xanthene-2-carboxylic acid::CHEMBL49210::LY-210073
SMILES: COc1ccc(\C=C\CCCCOc2ccc3c(oc4ccc(cc4c3=O)C(O)=O)c2CCC(O)=O)cc1
InChI Key: InChIKey=MTTBGOLFCYOWSV-GQCTYLIASA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Leukotriene B4 receptor (Homo sapiens (Human)) | BDBM50045092 (5-(2-Carboxy-ethyl)-6-[(E)-6-(4-methoxy-phenyl)-he...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Inhibition constant against binding of [3H]-LTB4 to human neutrophils | J Med Chem 36: 1726-34 (1993) BindingDB Entry DOI: 10.7270/Q2JQ1023 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leukotriene B4 receptor (Homo sapiens (Human)) | BDBM50045092 (5-(2-Carboxy-ethyl)-6-[(E)-6-(4-methoxy-phenyl)-he...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils | Bioorg Med Chem Lett 3: 1981-1984 (1993) Article DOI: 10.1016/S0960-894X(01)80999-9 BindingDB Entry DOI: 10.7270/Q2VH5P9R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leukotriene B4 receptor (Homo sapiens (Human)) | BDBM50045092 (5-(2-Carboxy-ethyl)-6-[(E)-6-(4-methoxy-phenyl)-he...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 133 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description The antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophils | J Med Chem 36: 1726-34 (1993) BindingDB Entry DOI: 10.7270/Q2JQ1023 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leukotriene B4 receptor (Homo sapiens (Human)) | BDBM50045092 (5-(2-Carboxy-ethyl)-6-[(E)-6-(4-methoxy-phenyl)-he...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils | Bioorg Med Chem Lett 3: 1981-1984 (1993) Article DOI: 10.1016/S0960-894X(01)80999-9 BindingDB Entry DOI: 10.7270/Q2VH5P9R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leukotriene B4 receptor (Homo sapiens (Human)) | BDBM50045092 (5-(2-Carboxy-ethyl)-6-[(E)-6-(4-methoxy-phenyl)-he...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils | J Med Chem 36: 1726-34 (1993) BindingDB Entry DOI: 10.7270/Q2JQ1023 | |||||||||||
More data for this Ligand-Target Pair |