null
SMILES: Cn1c2cc(Cc3ccc(F)cc3)cnc2c(O)c(C(=O)NCCO)c1=O
InChI Key: InChIKey=QWLNINWUBHHOLU-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Integrase (Human immunodeficiency virus 1) | BDBM50045107 (CHEMBL1256978 | GSK364735) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research& Development Curated by ChEMBL | Assay Description Inhibition of recombinant HIV-1 integrase by strand-transfer assay | Bioorg Med Chem Lett 24: 3104-7 (2014) Article DOI: 10.1016/j.bmcl.2014.05.011 BindingDB Entry DOI: 10.7270/Q2BC415P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50045107 (CHEMBL1256978 | GSK364735) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research& Development Curated by ChEMBL | Assay Description Inhibition of pseudotype HIV1 integrase strand transfer activity assessed as reduction in viral replication in HIV1 infected human CIP4 cells after 2... | Eur J Med Chem 117: 99-112 (2016) BindingDB Entry DOI: 10.7270/Q2G162R8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50045107 (CHEMBL1256978 | GSK364735) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of Human immunodeficiency virus 1 integrase by strand transfer scintillation proximity assay | Antimicrob Agents Chemother 52: 901-8 (2008) Article DOI: 10.1128/aac.01218-07 BindingDB Entry DOI: 10.7270/Q2JQ13VN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50045107 (CHEMBL1256978 | GSK364735) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Displacement of [3H]GSK304649 from Human immunodeficiency virus 1 integrase by scintillation proximity assay | Antimicrob Agents Chemother 52: 901-8 (2008) Article DOI: 10.1128/aac.01218-07 BindingDB Entry DOI: 10.7270/Q2JQ13VN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50045107 (CHEMBL1256978 | GSK364735) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Displacement of 20 nM [3H]GSK304649 from Human immunodeficiency virus 1 integrase by scintillation proximity assay | Antimicrob Agents Chemother 52: 901-8 (2008) Article DOI: 10.1128/aac.01218-07 BindingDB Entry DOI: 10.7270/Q2JQ13VN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50045107 (CHEMBL1256978 | GSK364735) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research & Development Curated by ChEMBL | Assay Description Inhibition of HIV1 integrase strand transfer activity | Bioorg Med Chem Lett 23: 422-5 (2013) Article DOI: 10.1016/j.bmcl.2012.11.071 BindingDB Entry DOI: 10.7270/Q2XK8JFB | |||||||||||
More data for this Ligand-Target Pair |