BDBM50046248 2-Amino-8-[(3-methyl-thiophen-2-ylmethyl)-amino]-1,9-dihydro-purin-6-one::CHEMBL350773

SMILES: Cc1ccsc1CNc1nc2nc(N)[nH]c(=O)c2[nH]1

InChI Key: InChIKey=VZJBSOZNPAOAMB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50046248   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50046248 (2-Amino-8-[(3-methyl-thiophen-2-ylmethyl)-amino]-1...) Show SMILES Cc1ccsc1CNc1nc2nc(N)[nH]c(=O)c2[nH]1 Show InChI InChI=1S/C11H12N6OS/c1-5-2-3-19-6(5)4-13-11-14-7-8(16-11)15-10(12)17-9(7)18/h2-3H,4H2,1H3,(H5,12,13,14,15,16,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate				J Med Chem 36: 55-69 (1993) BindingDB Entry DOI: 10.7270/Q2B27TCX
					More data for this Ligand-Target Pair