BDBM50047015 CHEMBL14474::Chinolin::benzo[b]pyridine::quinoline
SMILES: c1ccc2ncccc2c1
InChI Key: InChIKey=SMWDFEZZVXVKRB-UHFFFAOYSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM50047015 (CHEMBL14474 | Chinolin | benzo[b]pyridine | quinol...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars | PubMed | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut f£r Toxikologie Curated by ChEMBL | Assay Description Inhibitory effect on Bufuralol 1'-hydroxylation by human liver microsomes (Ki = apparent inhibition constant) | J Med Chem 36: 1136-45 (1993) BindingDB Entry DOI: 10.7270/Q2GM87X6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil cytosol factor 1 (Homo sapiens) | BDBM50047015 (CHEMBL14474 | Chinolin | benzo[b]pyridine | quinol...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | >2.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera... | J Med Chem 63: 1156-1177 (2020) Article DOI: 10.1021/acs.jmedchem.9b01492 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nicotinamide N-methyltransferase (Homo sapiens (Human)) | BDBM50047015 (CHEMBL14474 | Chinolin | benzo[b]pyridine | quinol...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 1.02E+8 | -1.41 | n/a | n/a | n/a | n/a | n/a | 8.6 | 37 |
Utrecht University | Assay Description Enzyme activity assays were performed as previously described with NNMT (16.25 ug/mL, 550 nM) in 50 mM Tris buffer (pH 8.6) containing 1 mM DTT (all ... | Biochemistry 55: 5307-15 (2016) Article DOI: 10.1021/acs.biochem.6b00733 BindingDB Entry DOI: 10.7270/Q2H130TH | |||||||||||
More data for this Ligand-Target Pair |