BDBM50048233 1-(2-Methoxy-phenyl)-4-(1-phenyl-1H-pyrrol-3-ylmethyl)-piperazine::CHEMBL28321
SMILES: COc1ccccc1N1CCN(Cc2ccn(c2)-c2ccccc2)CC1
InChI Key: InChIKey=UPXJKNQVKALXKP-UHFFFAOYSA-N
Data: 6 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50048233 (1-(2-Methoxy-phenyl)-4-(1-phenyl-1H-pyrrol-3-ylmet...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universitá di Bari Curated by ChEMBL | Assay Description In vitro binding affinity was measured at the cloned human Dopamine receptor D4.2 using [3H]-YM-09151-2 as radioligand. | J Med Chem 41: 4903-9 (1998) Article DOI: 10.1021/jm981041x BindingDB Entry DOI: 10.7270/Q2S46R3V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dopamine D2 receptor (Cercopithecus aethiops) | BDBM50048233 (1-(2-Methoxy-phenyl)-4-(1-phenyl-1H-pyrrol-3-ylmet...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation Curated by ChEMBL | Assay Description Displacement of [3H]-YM 09151 from african green monkey Dopamine receptor D2 | J Med Chem 38: 4950-2 (1996) BindingDB Entry DOI: 10.7270/Q2FX7B33 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50048233 (1-(2-Methoxy-phenyl)-4-(1-phenyl-1H-pyrrol-3-ylmet...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation Curated by ChEMBL | Assay Description Displacement of [3H]-YM 09151 from human Dopamine receptor D4 | J Med Chem 38: 4950-2 (1996) BindingDB Entry DOI: 10.7270/Q2FX7B33 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50048233 (1-(2-Methoxy-phenyl)-4-(1-phenyl-1H-pyrrol-3-ylmet...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universitá di Bari Curated by ChEMBL | Assay Description In vitro binding affinity was measured at the cloned human Dopamine receptor D2 using [3H]-spiroperidol as radioligand. | J Med Chem 41: 4903-9 (1998) Article DOI: 10.1021/jm981041x BindingDB Entry DOI: 10.7270/Q2S46R3V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50048233 (1-(2-Methoxy-phenyl)-4-(1-phenyl-1H-pyrrol-3-ylmet...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Displacement of [3H]-YM-09151-2 from human Dopamine receptor D4.2 expressed in baculovirus Sf9 cells | Bioorg Med Chem Lett 7: 1327-1330 (1997) Article DOI: 10.1016/S0960-894X(97)00218-7 BindingDB Entry DOI: 10.7270/Q2P55NJG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(3) dopamine receptor (Chlorocebus aethiops) | BDBM50048233 (1-(2-Methoxy-phenyl)-4-(1-phenyl-1H-pyrrol-3-ylmet...) | PDB MMDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation Curated by ChEMBL | Assay Description Displacement of [3H]-YM 09151 from african moonkey Dopamine receptor D3 | J Med Chem 38: 4950-2 (1996) BindingDB Entry DOI: 10.7270/Q2FX7B33 | |||||||||||
More data for this Ligand-Target Pair |