BDBM50048250 CHEMBL3310778

SMILES: Cc1cccc(c1)-c1nc(SCc2cccc(F)c2F)nc(O)c1C#N

InChI Key: InChIKey=PKCBWQGKMWSQOP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50048250   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50048250 (CHEMBL3310778) Show SMILES Cc1cccc(c1)-c1nc(SCc2cccc(F)c2F)nc(O)c1C#N Show InChI InChI=1S/C19H13F2N3OS/c1-11-4-2-5-12(8-11)17-14(9-22)18(25)24-19(23-17)26-10-13-6-3-7-15(20)16(13)21/h2-8H,10H2,1H3,(H,23,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Antagonist activity against human recombinant CXCR2 receptor expressed in CHO cell membranes by SPA based [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 24: 3285-90 (2014) Article DOI: 10.1016/j.bmcl.2014.06.011 BindingDB Entry DOI: 10.7270/Q2930VTJ
					More data for this Ligand-Target Pair