BDBM50048292 6-[4-Methoxy-3-(1-methyl-cyclohexyl)-phenyl]-naphthalene-2-carboxylic acid::CHEMBL345298
SMILES: COc1ccc(cc1C1(C)CCCCC1)-c1ccc2cc(ccc2c1)C(O)=O
InChI Key: InChIKey=SWIWERVMTLKNLQ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Retinoid receptor (Homo sapiens (Human)) | BDBM50048292 (6-[4-Methoxy-3-(1-methyl-cyclohexyl)-phenyl]-napht...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA Curated by ChEMBL | Assay Description Binding affinity to retinoic acid receptor beta using [3H]-CD 367 as radioligand | J Med Chem 38: 4993-5006 (1996) BindingDB Entry DOI: 10.7270/Q20G3J8S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid receptor (Homo sapiens (Human)) | BDBM50048292 (6-[4-Methoxy-3-(1-methyl-cyclohexyl)-phenyl]-napht...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA Curated by ChEMBL | Assay Description Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand | J Med Chem 38: 4993-5006 (1996) BindingDB Entry DOI: 10.7270/Q20G3J8S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid X receptor gamma/retinoic acid receptor alpha (Homo sapiens (Human)) | BDBM50048292 (6-[4-Methoxy-3-(1-methyl-cyclohexyl)-phenyl]-napht...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CIRD GALDERMA Curated by ChEMBL | Assay Description Binding affinity to retinoic acid receptor alpha using [3H]-CD 367 as radioligand | J Med Chem 38: 4993-5006 (1996) BindingDB Entry DOI: 10.7270/Q20G3J8S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor beta (Mus musculus) | BDBM50048292 (6-[4-Methoxy-3-(1-methyl-cyclohexyl)-phenyl]-napht...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.830 | n/a | n/a | n/a | n/a |
King's College Curated by ChEMBL | Assay Description Transactivation of GAL4-fused mouse RARbeta-LBD expressed in COS-7 cells after 24 hrs by bright-Glo reagent based assay | Bioorg Med Chem Lett 29: 995-1000 (2019) Article DOI: 10.1016/j.bmcl.2019.02.011 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor alpha (Mus musculus) | BDBM50048292 (6-[4-Methoxy-3-(1-methyl-cyclohexyl)-phenyl]-napht...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 9.20 | n/a | n/a | n/a | n/a |
King's College Curated by ChEMBL | Assay Description Transactivation of GAL4-fused mouse RARalpha-LBD expressed in COS-7 cells after 24 hrs by bright-Glo reagent based assay | Bioorg Med Chem Lett 29: 995-1000 (2019) Article DOI: 10.1016/j.bmcl.2019.02.011 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor gamma (Mus musculus) | BDBM50048292 (6-[4-Methoxy-3-(1-methyl-cyclohexyl)-phenyl]-napht...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 11 | n/a | n/a | n/a | n/a |
King's College Curated by ChEMBL | Assay Description Transactivation of GAL4-fused mouse RARgamma-LBD expressed in COS-7 cells after 24 hrs by bright-Glo reagent based assay | Bioorg Med Chem Lett 29: 995-1000 (2019) Article DOI: 10.1016/j.bmcl.2019.02.011 | |||||||||||
More data for this Ligand-Target Pair |