BDBM50048389 4-(8-Methyl-9H-1,3-dioxa-6,7-diaza-cyclohepta[f]inden-5-yl)-phenylamine::4-(8-Methyl-9H-1,3-dioxa-6,7-diaza-cyclohepta[f]inden-5-yl)-phenylamine (GYKI 52466)::CHEMBL275006::GYKI-52466

SMILES: CC1=NN=C(c2ccc(N)cc2)c2cc3OCOc3cc2C1

InChI Key: InChIKey=LFBZZHVSGAHQPP-UHFFFAOYSA-N

Data: 6 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50048389   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor AMPA 2/3 (Homo sapiens (Human))	BDBM50048389 (4-(8-Methyl-9H-1,3-dioxa-6,7-diaza-cyclohepta[f]in...) Show SMILES CC1=NN=C(c2ccc(N)cc2)c2cc3OCOc3cc2C1 |t:1,3| Show InChI InChI=1S/C17H15N3O2/c1-10-6-12-7-15-16(22-9-21-15)8-14(12)17(20-19-10)11-2-4-13(18)5-3-11/h2-5,7-8H,6,9,18H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents	Article PubMed	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Annunziata, 98168 Messina, Italy. Curated by ChEMBL					Assay Description Antagonist activity at closed state of GFP-tagged GluA2Qflip isoform (unknown origin) expressed in HEK293S cells assessed as reduction in glutamate-i...				Bioorg Med Chem 25: 3631-3637 (2017) Article DOI: 10.1016/j.bmc.2017.05.036 BindingDB Entry DOI: 10.7270/Q2TF00T9
					More data for this Ligand-Target Pair
Glutamate receptor AMPA 2/3 (Homo sapiens (Human))	BDBM50048389 (4-(8-Methyl-9H-1,3-dioxa-6,7-diaza-cyclohepta[f]in...) Show SMILES CC1=NN=C(c2ccc(N)cc2)c2cc3OCOc3cc2C1 |t:1,3| Show InChI InChI=1S/C17H15N3O2/c1-10-6-12-7-15-16(22-9-21-15)8-14(12)17(20-19-10)11-2-4-13(18)5-3-11/h2-5,7-8H,6,9,18H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents	Article PubMed	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Annunziata, 98168 Messina, Italy. Curated by ChEMBL					Assay Description Antagonist activity at open state of GFP-tagged GluA2Qflip isoform (unknown origin) expressed in HEK293S cells assessed as reduction in glutamate-ind...				Bioorg Med Chem 25: 3631-3637 (2017) Article DOI: 10.1016/j.bmc.2017.05.036 BindingDB Entry DOI: 10.7270/Q2TF00T9
					More data for this Ligand-Target Pair
GRIA3 (RAT)	BDBM50048389 (4-(8-Methyl-9H-1,3-dioxa-6,7-diaza-cyclohepta[f]in...) Show SMILES CC1=NN=C(c2ccc(N)cc2)c2cc3OCOc3cc2C1 |t:1,3| Show InChI InChI=1S/C17H15N3O2/c1-10-6-12-7-15-16(22-9-21-15)8-14(12)17(20-19-10)11-2-4-13(18)5-3-11/h2-5,7-8H,6,9,18H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by PDSP Ki Database									Mol Pharmacol 58: 1310-7 (2000) Article DOI: 10.1124/mol.58.6.1310 BindingDB Entry DOI: 10.7270/Q24X56B1
					More data for this Ligand-Target Pair
GRIA3 (Homo sapiens (Human))	BDBM50048389 (4-(8-Methyl-9H-1,3-dioxa-6,7-diaza-cyclohepta[f]in...) Show SMILES CC1=NN=C(c2ccc(N)cc2)c2cc3OCOc3cc2C1 |t:1,3| Show InChI InChI=1S/C17H15N3O2/c1-10-6-12-7-15-16(22-9-21-15)8-14(12)17(20-19-10)11-2-4-13(18)5-3-11/h2-5,7-8H,6,9,18H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SIBIA Neurosciences, Inc. Curated by PDSP Ki Database									J Pharmacol Exp Ther 285: 358-70 (1998) BindingDB Entry DOI: 10.7270/Q23R0RDM
					More data for this Ligand-Target Pair
GRIA3 (Homo sapiens (Human))	BDBM50048389 (4-(8-Methyl-9H-1,3-dioxa-6,7-diaza-cyclohepta[f]in...) Show SMILES CC1=NN=C(c2ccc(N)cc2)c2cc3OCOc3cc2C1 |t:1,3| Show InChI InChI=1S/C17H15N3O2/c1-10-6-12-7-15-16(22-9-21-15)8-14(12)17(20-19-10)11-2-4-13(18)5-3-11/h2-5,7-8H,6,9,18H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SIBIA Neurosciences, Inc. Curated by PDSP Ki Database									J Pharmacol Exp Ther 285: 358-70 (1998) BindingDB Entry DOI: 10.7270/Q23R0RDM
					More data for this Ligand-Target Pair
GRIA3 (RAT)	BDBM50048389 (4-(8-Methyl-9H-1,3-dioxa-6,7-diaza-cyclohepta[f]in...) Show SMILES CC1=NN=C(c2ccc(N)cc2)c2cc3OCOc3cc2C1 |t:1,3| Show InChI InChI=1S/C17H15N3O2/c1-10-6-12-7-15-16(22-9-21-15)8-14(12)17(20-19-10)11-2-4-13(18)5-3-11/h2-5,7-8H,6,9,18H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SIBIA Neurosciences, Inc. Curated by PDSP Ki Database									J Pharmacol Exp Ther 285: 358-70 (1998) BindingDB Entry DOI: 10.7270/Q23R0RDM
					More data for this Ligand-Target Pair