BindingDB PrimarySearch

BDBM50048403 1,1'-(Deca-4,6-diyne-1,10-diyl)bis(4-amino-2-methylquinolinium) Diiodide Hydrate::1-[10-(4-amino-2-methyl-1-quinoliniumyl)decyl]-2-methyl-4-quinoliniumamine::1-[10-(4-amino-2-methyl-1-quinoliniumyl)decyl]-2-methyl-4-quinoliniumamine dichloride::1-[10-(4-amino-2-methyl-1-quinoliniumyl)decyl]-2-methyl-4-quinoliniumamine dichloride ; Dequalinium::1-[10-(4-amino-2-methyl-1-quinoliniumyl)decyl]-2-methyl-4-quinoliniumamine(Deq)::1-[10-(4-amino-2-methyl-1-quinoliniumyl)decyl]-2-methyl-4-quinoliniumamine(dequalinium)::CHEMBL121663::DQ+::Dequalinium chloride::Dequqlinium::GNF-Pf-5483::dequalinium

SMILES: Cc1cc(=[NH2+])c2ccccc2n1CCCCCCCCCCn1c(C)cc(=[NH2+])c2ccccc12

InChI Key: InChIKey=PCSWXVJAIHCTMO-UHFFFAOYSA-P

Data: 2 KI 6 IC50 1 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50048403
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Small conductance calcium-activated potassium channel protein 3 (Rattus norvegicus)	BDBM50048403 (1,1'-(Deca-4,6-diyne-1,10-diyl)bis(4-amino-2-methy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
NeuroSearch A/S Curated by ChEMBL					Assay Description Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells				J Med Chem 51: 7625-34 (2009) Article DOI: 10.1021/jm800809f BindingDB Entry DOI: 10.7270/Q28S4QT0
NeuroSearch A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50048403 (1,1'-(Deca-4,6-diyne-1,10-diyl)bis(4-amino-2-methy...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	221	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Li£ge Curated by ChEMBL					Assay Description Displacement of [125I]apamin from SK channel in Wistar rat cortex				J Med Chem 50: 5070-5 (2007) Article DOI: 10.1021/jm070412j BindingDB Entry DOI: 10.7270/Q28055C0
University of Li£ge Curated by ChEMBL					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3) (Homo sapiens (Human))	BDBM50048403 (1,1'-(Deca-4,6-diyne-1,10-diyl)bis(4-amino-2-methy...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol Myers Squibb Co. Curated by ChEMBL					Assay Description Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assay				Bioorg Med Chem Lett 18: 5316-9 (2008) Article DOI: 10.1016/j.bmcl.2008.08.023 BindingDB Entry DOI: 10.7270/Q2N87BP1
Bristol Myers Squibb Co. Curated by ChEMBL					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50048403 (1,1'-(Deca-4,6-diyne-1,10-diyl)bis(4-amino-2-methy...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
Aristotelian University of Thessaloniki Curated by ChEMBL					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50048403 (1,1'-(Deca-4,6-diyne-1,10-diyl)bis(4-amino-2-methy...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	650	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
University College London Curated by ChEMBL					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50048403 (1,1'-(Deca-4,6-diyne-1,10-diyl)bis(4-amino-2-methy...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description SKCa-blocking activity by its ability to inhibit after hyperpolarization (AHP) in cultured rat sympathetic neurons				J Med Chem 39: 359-70 (1996) Article DOI: 10.1021/jm950520i BindingDB Entry DOI: 10.7270/Q2KD21M8
University College London Curated by ChEMBL					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3) (Homo sapiens (Human))	BDBM50048403 (1,1'-(Deca-4,6-diyne-1,10-diyl)bis(4-amino-2-methy...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol Myers Squibb Co. Curated by ChEMBL					Assay Description Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay				Bioorg Med Chem Lett 18: 5316-9 (2008) Article DOI: 10.1016/j.bmcl.2008.08.023 BindingDB Entry DOI: 10.7270/Q2N87BP1
Bristol Myers Squibb Co. Curated by ChEMBL					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (Rattus norvegicus)	BDBM50048403 (1,1'-(Deca-4,6-diyne-1,10-diyl)bis(4-amino-2-methy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a
NeuroSearch A/S Curated by ChEMBL					Assay Description Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique				J Med Chem 51: 7625-34 (2009) Article DOI: 10.1021/jm800809f BindingDB Entry DOI: 10.7270/Q28S4QT0
NeuroSearch A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50048403 (1,1'-(Deca-4,6-diyne-1,10-diyl)bis(4-amino-2-methy...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	740	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The SKCa-blocking action was assessed by its ability to inhibit the after hyperpolarization (AHP) in cultured rat sympathetic neurones				J Med Chem 38: 3536-46 (1995) Article DOI: 10.1021/jm00018a013 BindingDB Entry DOI: 10.7270/Q2T156CQ
University College London Curated by ChEMBL					More data for this Ligand-Target Pair