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SMILES: COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c(OCC(=O)NCCO)c1OC

InChI Key: InChIKey=QLROCGFGPAAMFW-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50048424   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))		BDBM50048424
PNG
(CHEMBL3315086)
Show SMILES COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c(OCC(=O)NCCO)c1OC
Show InChI InChI=1S/C19H20Cl2N2O6/c1-27-16-4-3-11(15(25)7-12-13(20)8-22-9-14(12)21)18(19(16)28-2)29-10-17(26)23-5-6-24/h3-4,8-9,24H,5-7,10H2,1-2H3,(H,23,26)
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Similars
Article
PubMed
n/an/a 17n/an/an/an/an/an/a



LEO Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMP

J Med Chem 57: 5893-903 (2014)


Article DOI: 10.1021/jm500378a
BindingDB Entry DOI: 10.7270/Q2CV4KC4
More data for this
Ligand-Target Pair