BDBM50049363 4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-1-(3-phenyl-propyl)-piperidine::CHEMBL77867
SMILES: Fc1ccc(cc1)C(OCCC1CCN(CCCc2ccccc2)CC1)c1ccc(F)cc1
InChI Key: InChIKey=QWAAKIRPIKMRGP-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50049363 (4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-1-(3-p...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDDK Curated by ChEMBL | Assay Description Binding affinity of the compound towards dopamine transporter (DAT) by using [125I]-RTI-55 radioligand | J Med Chem 45: 4371-4 (2002) BindingDB Entry DOI: 10.7270/Q2RF5TCP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50049363 (4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-1-(3-p...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of New Orleans Curated by ChEMBL | Assay Description Displacement of [3H]WIN-35428 from dopamine transporter of rat caudate putamen tissue | Bioorg Med Chem Lett 12: 2387-90 (2002) BindingDB Entry DOI: 10.7270/Q2X067KS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50049363 (4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-1-(3-p...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 68 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDDK Curated by ChEMBL | Assay Description Binding affinity for serotonin transporter (SERT) using [125I]-RTI-55 | J Med Chem 45: 4371-4 (2002) BindingDB Entry DOI: 10.7270/Q2RF5TCP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50049363 (4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-1-(3-p...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc. Curated by ChEMBL | Assay Description Binding affinity at serotonin transporter from rat brain striatal membrane by [3H]-citalopram displacement. | J Med Chem 39: 749-56 (1996) Article DOI: 10.1021/jm9506581 BindingDB Entry DOI: 10.7270/Q2VH5MX0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50049363 (4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-1-(3-p...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 16.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc. Curated by ChEMBL | Assay Description Binding affinity at dopamine transporter from rat striatal membrane tissue by [3H]-CFT displacement. | J Med Chem 39: 749-56 (1996) Article DOI: 10.1021/jm9506581 BindingDB Entry DOI: 10.7270/Q2VH5MX0 | |||||||||||
More data for this Ligand-Target Pair |