BDBM50049478 1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-yl}-1-oxopropan-2-yl]carbamoyl}-1-methylethan-1-aminium::1N-[1-benzyloxymethyl-2-[1-methylsulfonylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-1-yl]-2-oxo-(1R)-ethyl]-2-amino-2-methylpropanamide::1N-[1-benzyloxymethyl-2-[1-methylsulfonylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-1-yl]-2-oxo-(1R)-ethyl]-2-amino-2-methylpropanamide [3a(MK-0677)]::1N-[1-benzyloxymethyl-2-[1-methylsulfonylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-1-yl]-2-oxo-(1R)-ethyl]-2-amino-2-methylpropanamide(MK-0677)::CHEMBL13817::MK 0677::MK-0677::MK-677
SMILES: CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CN(c3ccccc23)S(C)(=O)=O)CC1
InChI Key: InChIKey=UMUPQWIGCOZEOY-JOCHJYFZSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ghrelin receptor (Homo sapiens (Human)) | BDBM50049478 (1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Binding Affinity of the compound against Growth hormone secretagogue receptor of swine using [35S]-MK-0677 as radioligand | J Med Chem 39: 1767-70 (1996) Article DOI: 10.1021/jm960054c BindingDB Entry DOI: 10.7270/Q2BK1BDG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
GHS-R1a:GHS-R1aE124Q (Homo sapiens (Human)) | BDBM50049478 (1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 8.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université Montpellier 1 | Assay Description Briefly, direct ligand binding experiments were performed using fluorescence energy transfer with the purified receptor labeled with Alexa Fluor 350 ... | J Biol Chem 288: 24656-65 (2013) Article DOI: 10.1074/jbc.M113.453423 BindingDB Entry DOI: 10.7270/Q2F18XKT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
GHS-R1a:GHS-R1b (Homo sapiens (Human)) | BDBM50049478 (1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...) | PDB MMDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 9.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université Montpellier 1 | Assay Description Briefly, direct ligand binding experiments were performed using fluorescence energy transfer with the purified receptor labeled with Alexa Fluor 350 ... | J Biol Chem 288: 24656-65 (2013) Article DOI: 10.1074/jbc.M113.453423 BindingDB Entry DOI: 10.7270/Q2F18XKT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
GHS-R1a:GHS-R1a (Homo sapiens (Human)) | BDBM50049478 (1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 10.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université Montpellier 1 | Assay Description Briefly, direct ligand binding experiments were performed using fluorescence energy transfer with the purified receptor labeled with Alexa Fluor 350 ... | J Biol Chem 288: 24656-65 (2013) Article DOI: 10.1074/jbc.M113.453423 BindingDB Entry DOI: 10.7270/Q2F18XKT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM50049478 (1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 65.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université Montpellier 1 | Assay Description Briefly, direct ligand binding experiments were performed using fluorescence energy transfer with the purified receptor labeled with Alexa Fluor 350 ... | J Biol Chem 288: 24656-65 (2013) Article DOI: 10.1074/jbc.M113.453423 BindingDB Entry DOI: 10.7270/Q2F18XKT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
GHS-R1a:GHS-R1a (Homo sapiens (Human)) | BDBM50049478 (1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 68.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université Montpellier 1 | Assay Description Briefly, direct ligand binding experiments were performed using fluorescence energy transfer with the purified receptor labeled with Alexa Fluor 350 ... | J Biol Chem 288: 24656-65 (2013) Article DOI: 10.1074/jbc.M113.453423 BindingDB Entry DOI: 10.7270/Q2F18XKT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
GHS-R1a:GHS-R1aE124Q (Homo sapiens (Human)) | BDBM50049478 (1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 68.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université Montpellier 1 | Assay Description Briefly, direct ligand binding experiments were performed using fluorescence energy transfer with the purified receptor labeled with Alexa Fluor 350 ... | J Biol Chem 288: 24656-65 (2013) Article DOI: 10.1074/jbc.M113.453423 BindingDB Entry DOI: 10.7270/Q2F18XKT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
GHS-R1a:GHS-R1b (Homo sapiens (Human)) | BDBM50049478 (1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...) | PDB MMDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 90.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université Montpellier 1 | Assay Description Briefly, direct ligand binding experiments were performed using fluorescence energy transfer with the purified receptor labeled with Alexa Fluor 350 ... | J Biol Chem 288: 24656-65 (2013) Article DOI: 10.1074/jbc.M113.453423 BindingDB Entry DOI: 10.7270/Q2F18XKT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM50049478 (1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed ... | Bioorg Med Chem Lett 11: 1955-7 (2001) BindingDB Entry DOI: 10.7270/Q2DF6RR2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM50049478 (1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano Curated by ChEMBL | Assay Description Agonist activity at human GHS-R1 | Bioorg Med Chem 15: 3054-64 (2007) Article DOI: 10.1016/j.bmc.2007.01.057 BindingDB Entry DOI: 10.7270/Q25M66HV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM50049478 (1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay | J Med Chem 61: 5974-5987 (2018) Article DOI: 10.1021/acs.jmedchem.8b00322 BindingDB Entry DOI: 10.7270/Q2WD433X | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM50049478 (1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 0.398 | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis | J Med Chem 61: 5974-5987 (2018) Article DOI: 10.1021/acs.jmedchem.8b00322 BindingDB Entry DOI: 10.7270/Q2WD433X | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM50049478 (1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis | J Med Chem 61: 5974-5987 (2018) Article DOI: 10.1021/acs.jmedchem.8b00322 BindingDB Entry DOI: 10.7270/Q2WD433X | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM50049478 (1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 0.760 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Montpellier I et II Curated by ChEMBL | Assay Description Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand | J Med Chem 46: 1191-203 (2003) Article DOI: 10.1021/jm020985q BindingDB Entry DOI: 10.7270/Q2HQ40NJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM50049478 (1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Montpellier I et II Curated by ChEMBL | Assay Description Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand | J Med Chem 46: 1191-203 (2003) Article DOI: 10.1021/jm020985q BindingDB Entry DOI: 10.7270/Q2HQ40NJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM50049478 (1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cells | J Med Chem 45: 5609-16 (2002) BindingDB Entry DOI: 10.7270/Q270825W | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM50049478 (1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Binding affinity for human growth hormone GH secretagogue (hGHsr) receptor | Bioorg Med Chem Lett 10: 5-8 (2000) BindingDB Entry DOI: 10.7270/Q2DV1KDR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM50049478 (1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S Curated by ChEMBL | Assay Description Inhibition of the compound against human growth hormone secretagogue (GHS) receptor | J Med Chem 47: 888-99 (2004) Article DOI: 10.1021/jm0309452 BindingDB Entry DOI: 10.7270/Q2SN08D0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM50049478 (1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay | J Med Chem 61: 5974-5987 (2018) Article DOI: 10.1021/acs.jmedchem.8b00322 BindingDB Entry DOI: 10.7270/Q2WD433X | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM50049478 (1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 0.140 | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Compound was evaluated for binding affinity using [35S]-MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activity | J Med Chem 41: 3103-27 (1998) Article DOI: 10.1021/jm970342o BindingDB Entry DOI: 10.7270/Q2D799KH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM50049478 (1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 0.630 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed ... | Bioorg Med Chem Lett 11: 1955-7 (2001) BindingDB Entry DOI: 10.7270/Q2DF6RR2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Ghrelin receptor () | BDBM50049478 (1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...) | Reactome pathway KEGG GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description In vitro growth hormone release was determined in rat pituitary cell assay | Bioorg Med Chem Lett 8: 107-12 (1999) BindingDB Entry DOI: 10.7270/Q2XS5TJX | |||||||||||
More data for this Ligand-Target Pair |