Found 4 hits for monomerid = 50049534 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50049534
(CHEMBL3319108)Show SMILES CC(C(=O)NCc1ccc(nc1-c1ccc(F)cc1)C(F)(F)F)c1ccc(NS(C)(=O)=O)c(F)c1 Show InChI InChI=1S/C23H20F5N3O3S/c1-13(15-5-9-19(18(25)11-15)31-35(2,33)34)22(32)29-12-16-6-10-20(23(26,27)28)30-21(16)14-3-7-17(24)8-4-14/h3-11,13,31H,12H2,1-2H3,(H,29,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Antagonist activity against human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced channel activation by FLIPR assay |
Bioorg Med Chem Lett 24: 4044-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.05.072 BindingDB Entry DOI: 10.7270/Q2JH3NTH |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50049534
(CHEMBL3319108)Show SMILES CC(C(=O)NCc1ccc(nc1-c1ccc(F)cc1)C(F)(F)F)c1ccc(NS(C)(=O)=O)c(F)c1 Show InChI InChI=1S/C23H20F5N3O3S/c1-13(15-5-9-19(18(25)11-15)31-35(2,33)34)22(32)29-12-16-6-10-20(23(26,27)28)30-21(16)14-3-7-17(24)8-4-14/h3-11,13,31H,12H2,1-2H3,(H,29,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.840 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Antagonist activity against human TRPV1 expressed in CHO cells assessed as inhibition of NADA-induced channel activation by FLIPR assay |
Bioorg Med Chem Lett 24: 4044-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.05.072 BindingDB Entry DOI: 10.7270/Q2JH3NTH |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50049534
(CHEMBL3319108)Show SMILES CC(C(=O)NCc1ccc(nc1-c1ccc(F)cc1)C(F)(F)F)c1ccc(NS(C)(=O)=O)c(F)c1 Show InChI InChI=1S/C23H20F5N3O3S/c1-13(15-5-9-19(18(25)11-15)31-35(2,33)34)22(32)29-12-16-6-10-20(23(26,27)28)30-21(16)14-3-7-17(24)8-4-14/h3-11,13,31H,12H2,1-2H3,(H,29,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Antagonist activity against human TRPV1 expressed in CHO cells assessed as inhibition of 45 degC heat-induced channel activation by FLIPR assay |
Bioorg Med Chem Lett 24: 4044-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.05.072 BindingDB Entry DOI: 10.7270/Q2JH3NTH |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50049534
(CHEMBL3319108)Show SMILES CC(C(=O)NCc1ccc(nc1-c1ccc(F)cc1)C(F)(F)F)c1ccc(NS(C)(=O)=O)c(F)c1 Show InChI InChI=1S/C23H20F5N3O3S/c1-13(15-5-9-19(18(25)11-15)31-35(2,33)34)22(32)29-12-16-6-10-20(23(26,27)28)30-21(16)14-3-7-17(24)8-4-14/h3-11,13,31H,12H2,1-2H3,(H,29,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 131 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Antagonist activity against human TRPV1 expressed in CHO cells assessed as inhibition of pH-induced channel activation by FLIPR assay |
Bioorg Med Chem Lett 24: 4044-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.05.072 BindingDB Entry DOI: 10.7270/Q2JH3NTH |
More data for this Ligand-Target Pair | |