BDBM50051166 1-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)pyrrolidine-2,5-dione::1-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-pyrrolidine-2,5-dione::CHEMBL279841

SMILES: COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1

InChI Key: InChIKey=MQHOGPLXAXSQAJ-UHFFFAOYSA-N

Data: 7 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50051166   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50051166 (1-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)pyrr...) Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1 Show InChI InChI=1S/C19H27N3O3/c1-25-17-7-3-2-6-16(17)21-14-12-20(13-15-21)10-4-5-11-22-18(23)8-9-19(22)24/h2-3,6-7H,4-5,8-15H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Polish Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine 1A receptor in the rat brain (hippocampus) using [3H]-8-OH-DPAT				J Med Chem 39: 1125-9 (1996) Article DOI: 10.1021/jm950662c BindingDB Entry DOI: 10.7270/Q21Z43H2
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50051166 (1-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)pyrr...) Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1 Show InChI InChI=1S/C19H27N3O3/c1-25-17-7-3-2-6-16(17)21-14-12-20(13-15-21)10-4-5-11-22-18(23)8-9-19(22)24/h2-3,6-7H,4-5,8-15H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Polish Academy of Sciences Curated by ChEMBL					Assay Description In vitro ability to displace the radioligand [3H]-OH-DPAT from binding to rat 5-hydroxytryptamine 1A receptor				Bioorg Med Chem Lett 14: 5863-6 (2004) Checked by Author Article DOI: 10.1016/j.bmcl.2004.09.029 BindingDB Entry DOI: 10.7270/Q22N51RZ
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50051166 (1-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)pyrr...) Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1 Show InChI InChI=1S/C19H27N3O3/c1-25-17-7-3-2-6-16(17)21-14-12-20(13-15-21)10-4-5-11-22-18(23)8-9-19(22)24/h2-3,6-7H,4-5,8-15H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Université Montpellier I et II Curated by ChEMBL					Assay Description Displacement of [3H]8-OH-DPAT from serotonin 5HT1A receptor in rat brain hippocampus				Bioorg Med Chem 15: 2907-19 (2007) Article DOI: 10.1016/j.bmc.2007.02.018 BindingDB Entry DOI: 10.7270/Q20G3JTZ
					More data for this Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50051166 (1-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)pyrr...) Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1 Show InChI InChI=1S/C19H27N3O3/c1-25-17-7-3-2-6-16(17)21-14-12-20(13-15-21)10-4-5-11-22-18(23)8-9-19(22)24/h2-3,6-7H,4-5,8-15H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Perugia Curated by ChEMBL					Assay Description Alpha-1 adrenergic receptor binding affinity of the compound, value taken from literature				J Med Chem 44: 2118-32 (2001) Article DOI: 10.1021/jm010821u BindingDB Entry DOI: 10.7270/Q2W3802N
					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Rattus norvegicus (rat))	BDBM50051166 (1-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)pyrr...) Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1 Show InChI InChI=1S/C19H27N3O3/c1-25-17-7-3-2-6-16(17)21-14-12-20(13-15-21)10-4-5-11-22-18(23)8-9-19(22)24/h2-3,6-7H,4-5,8-15H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Polish Academy of Sciences Curated by ChEMBL					Assay Description In vitro ability to displace the radioligand [3H]-5-CT from binding to rat 5-hydroxytryptamine 7 receptor				Bioorg Med Chem Lett 14: 5863-6 (2004) Checked by Author Article DOI: 10.1016/j.bmcl.2004.09.029 BindingDB Entry DOI: 10.7270/Q22N51RZ
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50051166 (1-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)pyrr...) Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1 Show InChI InChI=1S/C19H27N3O3/c1-25-17-7-3-2-6-16(17)21-14-12-20(13-15-21)10-4-5-11-22-18(23)8-9-19(22)24/h2-3,6-7H,4-5,8-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	490	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Université Montpellier I et II Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatal membrane				Bioorg Med Chem 15: 2907-19 (2007) Article DOI: 10.1016/j.bmc.2007.02.018 BindingDB Entry DOI: 10.7270/Q20G3JTZ
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50051166 (1-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)pyrr...) Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1 Show InChI InChI=1S/C19H27N3O3/c1-25-17-7-3-2-6-16(17)21-14-12-20(13-15-21)10-4-5-11-22-18(23)8-9-19(22)24/h2-3,6-7H,4-5,8-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.51E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Université Montpellier I et II Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin from serotonin 5HT2A receptor in rat brain cortex				Bioorg Med Chem 15: 2907-19 (2007) Article DOI: 10.1016/j.bmc.2007.02.018 BindingDB Entry DOI: 10.7270/Q20G3JTZ
					More data for this Ligand-Target Pair