BDBM50051310 CHEMBL433305::Phenyl-(6,7,8,9-tetrahydro-5H-pyrimido[4,5-b]indol-4-yl)-amine

SMILES: C1CCc2c(C1)[nH]c1ncnc(Nc3ccccc3)c21

InChI Key: InChIKey=ONNAZAHCACRHEO-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50051310   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50051310 (CHEMBL433305 | Phenyl-(6,7,8,9-tetrahydro-5H-pyrim...) Show SMILES C1CCc2c(C1)[nH]c1ncnc(Nc3ccccc3)c21 Show InChI InChI=1S/C16H16N4/c1-2-6-11(7-3-1)19-15-14-12-8-4-5-9-13(12)20-16(14)18-10-17-15/h1-3,6-7,10H,4-5,8-9H2,(H2,17,18,19,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
CIBA Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells expressing EGF-R				J Med Chem 39: 2285-92 (1996) Article DOI: 10.1021/jm960118j BindingDB Entry DOI: 10.7270/Q2J1028B
					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50051310 (CHEMBL433305 | Phenyl-(6,7,8,9-tetrahydro-5H-pyrim...) Show SMILES C1CCc2c(C1)[nH]c1ncnc(Nc3ccccc3)c21 Show InChI InChI=1S/C16H16N4/c1-2-6-11(7-3-1)19-15-14-12-8-4-5-9-13(12)20-16(14)18-10-17-15/h1-3,6-7,10H,4-5,8-9H2,(H2,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
CIBA Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Protein kinase C alpha				J Med Chem 39: 2285-92 (1996) Article DOI: 10.1021/jm960118j BindingDB Entry DOI: 10.7270/Q2J1028B
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50051310 (CHEMBL433305 | Phenyl-(6,7,8,9-tetrahydro-5H-pyrim...) Show SMILES C1CCc2c(C1)[nH]c1ncnc(Nc3ccccc3)c21 Show InChI InChI=1S/C16H16N4/c1-2-6-11(7-3-1)19-15-14-12-8-4-5-9-13(12)20-16(14)18-10-17-15/h1-3,6-7,10H,4-5,8-9H2,(H2,17,18,19,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
CIBA Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of tyrosine kinase c-Src				J Med Chem 39: 2285-92 (1996) Article DOI: 10.1021/jm960118j BindingDB Entry DOI: 10.7270/Q2J1028B
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50051310 (CHEMBL433305 | Phenyl-(6,7,8,9-tetrahydro-5H-pyrim...) Show SMILES C1CCc2c(C1)[nH]c1ncnc(Nc3ccccc3)c21 Show InChI InChI=1S/C16H16N4/c1-2-6-11(7-3-1)19-15-14-12-8-4-5-9-13(12)20-16(14)18-10-17-15/h1-3,6-7,10H,4-5,8-9H2,(H2,17,18,19,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
CIBA Pharmaceuticals Curated by ChEMBL					Assay Description In vitro inhibitory activity against epidermal growth factor receptor				J Med Chem 39: 2285-92 (1996) Article DOI: 10.1021/jm960118j BindingDB Entry DOI: 10.7270/Q2J1028B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL (Homo sapiens (Human))	BDBM50051310 (CHEMBL433305 | Phenyl-(6,7,8,9-tetrahydro-5H-pyrim...) Show SMILES C1CCc2c(C1)[nH]c1ncnc(Nc3ccccc3)c21 Show InChI InChI=1S/C16H16N4/c1-2-6-11(7-3-1)19-15-14-12-8-4-5-9-13(12)20-16(14)18-10-17-15/h1-3,6-7,10H,4-5,8-9H2,(H2,17,18,19,20)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
CIBA Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of tyrosine kinase v-Abl				J Med Chem 39: 2285-92 (1996) Article DOI: 10.1021/jm960118j BindingDB Entry DOI: 10.7270/Q2J1028B
					More data for this Ligand-Target Pair