BDBM50051375 (6S,8aS)-5,5,8a-Trimethyl-2-((E)-1,5,9-trimethyl-deca-4,8-dienyl)-1,2,3,5,6,7,8,8a-octahydro-isoquinolin-6-ol::CHEMBL76239
SMILES: [#6]-[#6](-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])-[#7]-1-[#6]-[#6]=[#6]2C([#6])([#6])[#6@@H](-[#8])-[#6]-[#6][C@]2([#6])[#6]-1
InChI Key: InChIKey=CKIQSCJROIUFAT-XAYFZMMHSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lanosterol synthase (Rattus norvegicus) | BDBM50051375 ((6S,8aS)-5,5,8a-Trimethyl-2-((E)-1,5,9-trimethyl-d...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires Fournier SCA Curated by ChEMBL | Assay Description Binding affinity towards competitive inhibition against rat microsomal Oxidosqualene-lanosterol cyclase | J Med Chem 39: 2302-12 (1996) Article DOI: 10.1021/jm9504621 BindingDB Entry DOI: 10.7270/Q28G8JTB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lanosterol synthase (Rattus norvegicus) | BDBM50051375 ((6S,8aS)-5,5,8a-Trimethyl-2-((E)-1,5,9-trimethyl-d...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires Fournier SCA Curated by ChEMBL | Assay Description Binding affinity towards noncompetetive inhibition against rat microsomal Oxidosqualene-lanosterol cyclase | J Med Chem 39: 2302-12 (1996) Article DOI: 10.1021/jm9504621 BindingDB Entry DOI: 10.7270/Q28G8JTB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lanosterol synthase (Rattus norvegicus) | BDBM50051375 ((6S,8aS)-5,5,8a-Trimethyl-2-((E)-1,5,9-trimethyl-d...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires Fournier SCA Curated by ChEMBL | Assay Description Inhibitory activity against Oxidosqualene-lanosterol cyclase from Rat liver microsomes | J Med Chem 39: 2302-12 (1996) Article DOI: 10.1021/jm9504621 BindingDB Entry DOI: 10.7270/Q28G8JTB | |||||||||||
More data for this Ligand-Target Pair |