BDBM50051884 1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl]-3,5-dimethyl-1H-pyrazole::CHEMBL33661::Diphenylimidazole analogue
SMILES: Cc1cc(C)n(CCCCCS(=O)c2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1
InChI Key: InChIKey=POQMHHDKXWTFHB-UHFFFAOYSA-N
Data: 12 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Acyl-CoA:cholesterol acyltransferase (Oryctolagus cuniculus) | BDBM50051884 (1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...) | PDB Reactome pathway KEGG UniProtKB/TrEMBL DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 245 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from rabbit artery. | Bioorg Med Chem Lett 6: 47-50 (1996) Article DOI: 10.1016/0960-894X(95)00555-8 BindingDB Entry DOI: 10.7270/Q2N29WXG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-CoA:cholesterol acyltransferase (Oryctolagus cuniculus) | BDBM50051884 (1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...) | PDB Reactome pathway KEGG UniProtKB/TrEMBL DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer Curated by ChEMBL | Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% activity of the rabbit liver Acyl coenzyme A:choleste... | J Med Chem 39: 1423-32 (1996) Article DOI: 10.1021/jm9505876 BindingDB Entry DOI: 10.7270/Q2TB160C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50051884 (1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer Curated by ChEMBL | Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ... | J Med Chem 39: 1423-32 (1996) Article DOI: 10.1021/jm9505876 BindingDB Entry DOI: 10.7270/Q2TB160C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-CoA:cholesterol acyltransferase (Oryctolagus cuniculus) | BDBM50051884 (1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...) | PDB Reactome pathway KEGG UniProtKB/TrEMBL DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer Curated by ChEMBL | Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% activity of the rabbit artery Acyl coenzyme A:cholest... | J Med Chem 39: 1423-32 (1996) Article DOI: 10.1021/jm9505876 BindingDB Entry DOI: 10.7270/Q2TB160C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase, Soat (Rattus norvegicus) | BDBM50051884 (1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer Curated by ChEMBL | Assay Description In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver. | J Med Chem 39: 1423-32 (1996) Article DOI: 10.1021/jm9505876 BindingDB Entry DOI: 10.7270/Q2TB160C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50051884 (1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 108 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from HEP G2 cells. | Bioorg Med Chem Lett 6: 47-50 (1996) Article DOI: 10.1016/0960-894X(95)00555-8 BindingDB Entry DOI: 10.7270/Q2N29WXG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-CoA:cholesterol acyltransferase (Oryctolagus cuniculus) | BDBM50051884 (1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...) | PDB Reactome pathway KEGG UniProtKB/TrEMBL DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 122 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from rabbit intestine. | Bioorg Med Chem Lett 6: 47-50 (1996) Article DOI: 10.1016/0960-894X(95)00555-8 BindingDB Entry DOI: 10.7270/Q2N29WXG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-CoA:cholesterol acyltransferase (Oryctolagus cuniculus) | BDBM50051884 (1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...) | PDB Reactome pathway KEGG UniProtKB/TrEMBL DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from rabbit adrenal. | Bioorg Med Chem Lett 6: 47-50 (1996) Article DOI: 10.1016/0960-894X(95)00555-8 BindingDB Entry DOI: 10.7270/Q2N29WXG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-CoA:cholesterol acyltransferase (Oryctolagus cuniculus) | BDBM50051884 (1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...) | PDB Reactome pathway KEGG UniProtKB/TrEMBL DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 208 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from rabbit intestine. | Bioorg Med Chem Lett 6: 47-50 (1996) Article DOI: 10.1016/0960-894X(95)00555-8 BindingDB Entry DOI: 10.7270/Q2N29WXG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50051884 (1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 164 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from THP-1 cells. | Bioorg Med Chem Lett 6: 47-50 (1996) Article DOI: 10.1016/0960-894X(95)00555-8 BindingDB Entry DOI: 10.7270/Q2N29WXG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase, Soat (Rattus norvegicus) | BDBM50051884 (1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 86 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from rat liver | Bioorg Med Chem Lett 6: 47-50 (1996) Article DOI: 10.1016/0960-894X(95)00555-8 BindingDB Entry DOI: 10.7270/Q2N29WXG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50051884 (1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer Curated by ChEMBL | Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% activity of the rabbit liver Acyl coenzyme A:choleste... | J Med Chem 39: 1423-32 (1996) Article DOI: 10.1021/jm9505876 BindingDB Entry DOI: 10.7270/Q2TB160C | |||||||||||
More data for this Ligand-Target Pair |