BindingDB PrimarySearch

BDBM50052039 18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::CHEMBL292495::LY-326449

SMILES: OC[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21

InChI Key: InChIKey=BGVKOUSMQGMSDY-INIZCTEOSA-N

Data: 11 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50052039
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50052039 (18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacy...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	720	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Protein kinase C alpha				J Med Chem 39: 2664-71 (1996) Article DOI: 10.1021/jm950588y BindingDB Entry DOI: 10.7270/Q25H7FBV
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C, eta (Homo sapiens (Human))	BDBM50052039 (18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacy...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Protein kinase C eta				J Med Chem 39: 2664-71 (1996) Article DOI: 10.1021/jm950588y BindingDB Entry DOI: 10.7270/Q25H7FBV
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
PKC alpha and beta-2 (Homo sapiens (Human))	BDBM50052039 (18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacy...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Protein kinase C beta 2				J Med Chem 39: 2664-71 (1996) Article DOI: 10.1021/jm950588y BindingDB Entry DOI: 10.7270/Q25H7FBV
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50052039 (18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacy...) Show SMILES Show InChI	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of src kinase				J Med Chem 39: 2664-71 (1996) Article DOI: 10.1021/jm950588y BindingDB Entry DOI: 10.7270/Q25H7FBV
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
PKC alpha and beta-2 (Homo sapiens (Human))	BDBM50052039 (18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacy...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Protein kinase C beta 1				J Med Chem 39: 2664-71 (1996) Article DOI: 10.1021/jm950588y BindingDB Entry DOI: 10.7270/Q25H7FBV
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C (PKC) (Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)	BDBM50052039 (18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacy...) Show SMILES Show InChI	PDB GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of rat brain PKC				Bioorg Med Chem Lett 5: 2093-2096 (1995) Article DOI: 10.1016/0960-894X(95)00350-3 BindingDB Entry DOI: 10.7270/Q2D50MXM
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C, epsilon (Homo sapiens (Human))	BDBM50052039 (18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacy...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Protein kinase C epsilon				J Med Chem 39: 2664-71 (1996) Article DOI: 10.1021/jm950588y BindingDB Entry DOI: 10.7270/Q25H7FBV
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C (PKC) (Homo sapiens (Human))	BDBM50052039 (18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacy...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Protein kinase C zeta				J Med Chem 39: 2664-71 (1996) Article DOI: 10.1021/jm950588y BindingDB Entry DOI: 10.7270/Q25H7FBV
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C, gamma (Homo sapiens (Human))	BDBM50052039 (18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacy...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Protein kinase C gamma				J Med Chem 39: 2664-71 (1996) Article DOI: 10.1021/jm950588y BindingDB Entry DOI: 10.7270/Q25H7FBV
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
PKC alpha and beta-2 (Homo sapiens (Human))	BDBM50052039 (18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacy...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Protein kinase C beta 2				Bioorg Med Chem Lett 5: 2093-2096 (1995) Article DOI: 10.1016/0960-894X(95)00350-3 BindingDB Entry DOI: 10.7270/Q2D50MXM
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C delta type (Homo sapiens (Human))	BDBM50052039 (18-hydroxymethyl-(18S)-17-oxa-4,14,21-triazahexacy...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	690	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Protein kinase C delta				J Med Chem 39: 2664-71 (1996) Article DOI: 10.1021/jm950588y BindingDB Entry DOI: 10.7270/Q25H7FBV
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair