BDBM50052098 CHEMBL285361::[3-Hydroxymethyl-6,7-dimethoxy-1-(3,4,5-trimethoxy-phenyl)-naphthalen-2-yl]-methanol

SMILES: COc1cc2cc(CO)c(CO)c(-c3cc(OC)c(OC)c(OC)c3)c2cc1OC

InChI Key: InChIKey=NZKILVAZKDWRAR-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50052098   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50052098 (CHEMBL285361 | [3-Hydroxymethyl-6,7-dimethoxy-1-(3...) Show SMILES COc1cc2cc(CO)c(CO)c(-c3cc(OC)c(OC)c(OC)c3)c2cc1OC Show InChI InChI=1S/C23H26O7/c1-26-18-7-13-6-15(11-24)17(12-25)22(16(13)10-19(18)27-2)14-8-20(28-3)23(30-5)21(9-14)29-4/h6-10,24-25H,11-12H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tan£be Seiyaku Company, Ltd. Curated by ChEMBL					Assay Description Inhibition in vitro of Phosphodiesterase 5 isolated from guinea pig lung				J Med Chem 39: 2696-704 (1996) Article DOI: 10.1021/jm9509096 BindingDB Entry DOI: 10.7270/Q2WS8TW7
					More data for this Ligand-Target Pair
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50052098 (CHEMBL285361 | [3-Hydroxymethyl-6,7-dimethoxy-1-(3...) Show SMILES COc1cc2cc(CO)c(CO)c(-c3cc(OC)c(OC)c(OC)c3)c2cc1OC Show InChI InChI=1S/C23H26O7/c1-26-18-7-13-6-15(11-24)17(12-25)22(16(13)10-19(18)27-2)14-8-20(28-3)23(30-5)21(9-14)29-4/h6-10,24-25H,11-12H2,1-5H3	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	880	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase 3 (PDE 3) isolated from cardiac ventricle				J Med Chem 42: 1293-305 (1999) Article DOI: 10.1021/jm9807048 BindingDB Entry DOI: 10.7270/Q27P8XKH
					More data for this Ligand-Target Pair
Phosphodiesterase 1 (Homo sapiens (Human))	BDBM50052098 (CHEMBL285361 | [3-Hydroxymethyl-6,7-dimethoxy-1-(3...) Show SMILES COc1cc2cc(CO)c(CO)c(-c3cc(OC)c(OC)c(OC)c3)c2cc1OC Show InChI InChI=1S/C23H26O7/c1-26-18-7-13-6-15(11-24)17(12-25)22(16(13)10-19(18)27-2)14-8-20(28-3)23(30-5)21(9-14)29-4/h6-10,24-25H,11-12H2,1-5H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase 1 (PDE I), isolated from cardiac ventricle				J Med Chem 42: 1293-305 (1999) Article DOI: 10.1021/jm9807048 BindingDB Entry DOI: 10.7270/Q27P8XKH
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Canis lupus familiaris)	BDBM50052098 (CHEMBL285361 | [3-Hydroxymethyl-6,7-dimethoxy-1-(3...) Show SMILES COc1cc2cc(CO)c(CO)c(-c3cc(OC)c(OC)c(OC)c3)c2cc1OC Show InChI InChI=1S/C23H26O7/c1-26-18-7-13-6-15(11-24)17(12-25)22(16(13)10-19(18)27-2)14-8-20(28-3)23(30-5)21(9-14)29-4/h6-10,24-25H,11-12H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase 5 (PDE V), isolated from cardiac ventricle				J Med Chem 42: 1293-305 (1999) Article DOI: 10.1021/jm9807048 BindingDB Entry DOI: 10.7270/Q27P8XKH
					More data for this Ligand-Target Pair