BDBM50052683 CHEMBL112449::N-[3-((Z)-2-Cyano-2-pyridin-3-yl-vinyl)-4-methyl-phenyl]-3-cyclohexyl-propionamide

SMILES: Cc1ccc(NC(=O)CCC2CCCCC2)cc1\C=C(/C#N)c1cccnc1

InChI Key: InChIKey=FWRQTZPEKIUTMG-HYARGMPZSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50052683   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
LDL receptor (Homo sapiens (Human))	BDBM50052683 (CHEMBL112449 | N-[3-((Z)-2-Cyano-2-pyridin-3-yl-vi...) Show SMILES Cc1ccc(NC(=O)CCC2CCCCC2)cc1\C=C(/C#N)c1cccnc1 Show InChI InChI=1S/C24H27N3O/c1-18-9-11-23(27-24(28)12-10-19-6-3-2-4-7-19)15-21(18)14-22(16-25)20-8-5-13-26-17-20/h5,8-9,11,13-15,17,19H,2-4,6-7,10,12H2,1H3,(H,27,28)/b22-14+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Concentration at which one-half of the maximum Low density lipoprotein receptor is upregulated in HepG2 cells				J Med Chem 39: 3343-56 (1996) Article DOI: 10.1021/jm960153q BindingDB Entry DOI: 10.7270/Q2FT8K4S
					More data for this Ligand-Target Pair