BDBM50053041 CHEMBL3318759

SMILES: C[C@]1(CC(O)=O)C[C@@H]([C@H](N([C@H](CS(=O)(=O)NCC2CCC2)C2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1

InChI Key: InChIKey=NOJSWEHJYONNRA-QXMDYEBFSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50053041   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2-MDMX (Homo sapiens (Human))	BDBM50053041 (CHEMBL3318759) Show SMILES C[C@]1(CC(O)=O)C[C@@H]([C@H](N([C@H](CS(=O)(=O)NCC2CCC2)C2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C30H36Cl2N2O5S/c1-30(16-27(35)36)15-25(22-6-3-7-24(32)14-22)28(21-10-12-23(31)13-11-21)34(29(30)37)26(20-8-9-20)18-40(38,39)33-17-19-4-2-5-19/h3,6-7,10-14,19-20,25-26,28,33H,2,4-5,8-9,15-18H2,1H3,(H,35,36)/t25-,26-,28-,30-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Binding affinity to human GST-thrombin-tagged MDM2 assessed as inhibition of interaction with human p53 after 1 hr by HTRF assay in presence of 15% h...				Bioorg Med Chem Lett 24: 3782-5 (2014) Article DOI: 10.1016/j.bmcl.2014.06.073 BindingDB Entry DOI: 10.7270/Q2ZC84HH
					More data for this Ligand-Target Pair