BDBM50053045 CHEMBL3318755::US9296736, 376::US9593129, Example 376

SMILES: CNS(=O)(=O)C[C@H](C1CC1)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1

InChI Key: InChIKey=TUDCVMKUXPXOII-HLMLHLEXSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50053045   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2 and p53 (Homo sapiens (Human))	BDBM50053045 (CHEMBL3318755 | US9296736, 376 | US9593129, Exampl...) Show SMILES CNS(=O)(=O)C[C@H](C1CC1)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C26H30Cl2N2O5S/c1-26(14-23(31)32)13-21(18-4-3-5-20(28)12-18)24(17-8-10-19(27)11-9-17)30(25(26)33)22(16-6-7-16)15-36(34,35)29-2/h3-5,8-12,16,21-22,24,29H,6-7,13-15H2,1-2H3,(H,31,32)/t21-,22-,24-,26-/m1/s1	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.4	25
Amgen INC. US Patent					Assay Description The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...				US Patent US9296736 (2016) BindingDB Entry DOI: 10.7270/Q29022M2
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (aa 1-188) (Homo sapiens (Human))	BDBM50053045 (CHEMBL3318755 | US9296736, 376 | US9593129, Exampl...) Show SMILES CNS(=O)(=O)C[C@H](C1CC1)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C26H30Cl2N2O5S/c1-26(14-23(31)32)13-21(18-4-3-5-20(28)12-18)24(17-8-10-19(27)11-9-17)30(25(26)33)22(16-6-7-16)15-36(34,35)29-2/h3-5,8-12,16,21-22,24,29H,6-7,13-15H2,1-2H3,(H,31,32)/t21-,22-,24-,26-/m1/s1	PDB GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. US Patent					Assay Description The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...				US Patent US9593129 (2017) BindingDB Entry DOI: 10.7270/Q20P1232
					More data for this Ligand-Target Pair
MDM2-MDMX (Homo sapiens (Human))	BDBM50053045 (CHEMBL3318755 | US9296736, 376 | US9593129, Exampl...) Show SMILES CNS(=O)(=O)C[C@H](C1CC1)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C26H30Cl2N2O5S/c1-26(14-23(31)32)13-21(18-4-3-5-20(28)12-18)24(17-8-10-19(27)11-9-17)30(25(26)33)22(16-6-7-16)15-36(34,35)29-2/h3-5,8-12,16,21-22,24,29H,6-7,13-15H2,1-2H3,(H,31,32)/t21-,22-,24-,26-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.980	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Binding affinity to human GST-thrombin-tagged MDM2 assessed as inhibition of interaction with human p53 after 1 hr by HTRF assay in presence of 15% h...				Bioorg Med Chem Lett 24: 3782-5 (2014) Article DOI: 10.1016/j.bmcl.2014.06.073 BindingDB Entry DOI: 10.7270/Q2ZC84HH
					More data for this Ligand-Target Pair