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SMILES: C[C@]1(CC(O)=O)C[C@@H]([C@H](N([C@H](CS(=O)(=O)Nc2ccccn2)C2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1

InChI Key: InChIKey=IOERNUZYYASLES-MFTQKCFDSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50053055   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM50053055
PNG
(CHEMBL3318770)
Show SMILES C[C@]1(CC(O)=O)C[C@@H]([C@H](N([C@H](CS(=O)(=O)Nc2ccccn2)C2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C30H31Cl2N3O5S/c1-30(17-27(36)37)16-24(21-5-4-6-23(32)15-21)28(20-10-12-22(31)13-11-20)35(29(30)38)25(19-8-9-19)18-41(39,40)34-26-7-2-3-14-33-26/h2-7,10-15,19,24-25,28H,8-9,16-18H2,1H3,(H,33,34)(H,36,37)/t24-,25-,28-,30-/m1/s1
PDB
MMDB

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Reactome pathway
KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 0.160n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GST-thrombin-tagged MDM2 assessed as inhibition of interaction with human p53 after 1 hr by HTRF assay in presence of 15% h...

Bioorg Med Chem Lett 24: 3782-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.073
BindingDB Entry DOI: 10.7270/Q2ZC84HH
More data for this
Ligand-Target Pair