BDBM50053056 CHEMBL3318771

SMILES: CCN(c1ccccc1)S(=O)(=O)C[C@H](C1CC1)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1

InChI Key: InChIKey=BUZGCPSWKFNSRE-CARYDLSXSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50053056   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2-MDMX (Homo sapiens (Human))	BDBM50053056 (CHEMBL3318771) Show SMILES CCN(c1ccccc1)S(=O)(=O)C[C@H](C1CC1)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C33H36Cl2N2O5S/c1-3-36(27-10-5-4-6-11-27)43(41,42)21-29(22-12-13-22)37-31(23-14-16-25(34)17-15-23)28(24-8-7-9-26(35)18-24)19-33(2,32(37)40)20-30(38)39/h4-11,14-18,22,28-29,31H,3,12-13,19-21H2,1-2H3,(H,38,39)/t28-,29-,31-,33-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0750	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Binding affinity to human GST-thrombin-tagged MDM2 assessed as inhibition of interaction with human p53 after 1 hr by HTRF assay in presence of 15% h...				Bioorg Med Chem Lett 24: 3782-5 (2014) Article DOI: 10.1016/j.bmcl.2014.06.073 BindingDB Entry DOI: 10.7270/Q2ZC84HH
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